Orthodontic tooth movement and root resorption after different doses of Celecoxib drug treatment in Rats

Non- Steroidal Anti Inflammatory (NSAIDs) medications used for treatment of pain related to orthodontic treatment could slow down tooth movements. Selective cyclooxigenase- 2 inhibitors are alternatives to conventional non steroidal drugs. The aim of this study was to compare three different doses of Celecoxib on orthodontic tooth movement and root resorption in Rats.

Forty male Rats randomly divided in to the following groups; D (the application of orthodontic appliance with taking medications); E (without any intervention) and experimental groups included A (received 25 mg/kg), B (received 50 mg/kg) and C (received 100 mg/kg) dose of Celecoxib. NiTi coil spring was ligated between the right side maxillary incisor and 1st molar. The animals were sacrificed after two weeks and distance between 2 teeth was measured with Caliper. After preparation of histological sections, amount of root resorption, numbers and maximum depth of resorption lacunae in mesial root surfaces of molar was measured. Data were analyzed with ANOVA, LSD and Tukey HSD.

The maximum tooth movement was found in group A (0.8537 mm), D, C, B and E respectively. Statistical analysis did not show any significant difference between the different doses of Celecoxib drug in tooth movement. The usage of Celecoxib (particularly in higher doses; 100 mg/kg) decreased the number of resorption lacaunae in mesial root of first maxillary molar (P< 0.05).

100 mg/kg dose of celecoxib was found to be optimum for the lowest effect on tooth movement and the most protection against root resorption.