Efficacy of Prophylactic Use of Sulindac in Comparison with Ibuprofen on

Endodontic treatment causes local trauma and subsequent inflammation, making pain and discomfort common side effects of endodontic treatment. Since there is an important relationship between post- endodontic pain and preendodontic pain, use of non-steroidal anti-inflammatory drugs (NSAIDs) before root canal therapy can suppress the inflammatory process before it starts, and reduce the pain after root canal therapy. The aim of this study was to compare the efficacy of prophylactic Ibuprofen Sulindac (both are NSAIDs) and placebo in controlling pain after root canal therapy. In this triple-blind clinical trial study, 48 patients with vital, single rooted anterior teeth were selected. These teeth were divided into three groups. One capsule was given to every group as prophylaxis before the treatment, which according to its code, contained Ibuprofen, Sulindac, or placebo. The treatment was then performed by one person (a general practitioner) according to standard methods. The pain of each patient was recorded before treatment and at 6, 12, 24, 48, and 72 hours after the treatment using a VAS scale. The results were collected and comparison of the means of pain between the three groups was conducted statistically. A reduction in pain was seen in Sulindac and Ibuprofen group at 6,12,24,48, and 72 hours after treatment compared to before treatment and placebo group, but the difference was not statistically significant (P>0.05). Since no statistically significant difference was observed between the groups, prophylactic use of these drugs for reduction of post-endodontic pain is not suggested.