Association between C-reactive protein and high-density lipoprotein of cholesterol among adults in Tehran city

In the present research, the association between C-reactive protein (CRP) and high-density lipoprotein of cholesterol (HDL-C) is studied among healthy adults in Tehran city.

It is performed as a cross-sectional study using data of adults with age 18 and more enrolled in the first phase of the "Evaluation of novel risk factors of NCD" project in the Research Institute for Endocrine Sciences (Tehran,Iran) in 2001. Analyses were done by logistic regression models using crude and adjusted odds ratio (OR) to demonstrate the associations between CRP and HDL-C regarding their age, gender, body mass index and smoking status as underlying variables. To get final reduced logistic model we used backward elimination strategy with likelihood ratio test.

Based on the findings of analysis on data of 126 men and 208 women, it was reported a significant association between blood concentration of CRP and HDL-C (P<0.001). Logistic regression analysis revealed that increasing the concentration of CRP to 0.2 mg/l and more in serum, increased the likelihood of decreasing the serum concentration of HDL-C to 40 and 50 mg/dl and less about two folds in men and women respectively (adjusted OR: 2.25, 95% CI: 1.49-3.41).

In apparently healthy adults from Tehran city, independent of age, sex, body mass index, blood pressure, fasting blood sugar, and smoking, serum concentrations of CRP and HDL-C are reversely associated while both of them are considered as independent factors related with cardiovascular disorders and complications.