Increased Expression of PPARγ1 in the Differentiation of Mouse Embryonic Stem Cells into Definitive Endoderm

Author(s):

Khadijeh Shabani , Kamran Ghaedi , Somayeh Tanhaie , Khadijeh Karbalaie , Ahmad Salamian , Farzaneh Rabiee , Ali Farrokhi , Mohammad Hossein Nasr-Esfahani , Hossein Baharvand

Message:
Abstract:

Peroxisome Proliferator-Activated Receptor γ (PPARγ) belongs to the nuclear receptor dependent ligand-activated transcription factors that regulates expression of many genes involved in metabolism, cell differentiation, adipogenesis, inflammation and apoptosis. Despite numerous studies which have been published on PPARγ activation during ectodermal differentiation, there are a limited number of studies on the role of PPARγ in endodermal differentiation. Thus, the aim of this study was to assess the expression of PPARγ during in vitro differentiation of mouse embryonic stem cells (mESCs) into definitive endoderm (DE). In this study we demonstrated that an increase of PPARγ expression profile occurred upon retinoic acid (RA) treatment in the process of differentiation. This may arise from a possible role of PPARγ in the process of endodermal differentiation which should be clarified in further studies.

Language:
English
Published:
Genetics in the Third Millennium, Volume:9 Issue: 3, 2012
Page:
2543
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