Abnormal movements and it,s related factors following propofol induction

Propofol is the first line drug for intravenous induction of anesthesia. Short action duration and few adverse effects along with potent antiemetic properties made it the most widely used drug Spontaneous movement or myoclonus is one of its adverse effects. We aimed to study the incidence, time of onset, quantity, and quality of the myoclonus and its related factors. The study was conducted on 204 patients who received Propofol for induction while observed by two anesthesiologists for detecting myoclonus. All patients were monitored for depth of anesthesia according to Bispectral index. The abnormal movement was recorded according to movement score. To find the relationship between myoclonus and other variables, logistic regression was applied. All analysis were done using software SPSS version 16. 60 patients out of 204 developed myoclonus corresponding with an incidence of 29%. The mean weight in these patients was significantly lower than the patients without myoclonus and they received higher dose of Propofol per kilogram of body weight. Multivariate logistic regression corroborates the relation of age and dose with the incidence of myoclonus. Comparing this study with other studies, a hypothesis about the impact of race on the dose of Propofol required to achieve the planned level of anesthesia is figured out. The difference in dose requirement between races and the importance for prevention of myoclonus remains to be studied in large multicentre studies.