Associations Between Hormonal Profiles of Urban Iranian Women of Reproductive age: A Community Based Study of Four Provinces

Differences in prevalences of metabolic and cardiovascular disease (CVD) between men and women could be a result of differences in their hormonal profiles. In this study we aimed to examine the association between hormonal profiles and metabolic syndrome parameters in reproductive aged women. From 1126 non-menopause women, aged between 18-45 years, using the stratified, multistage probability cluster sampling method, 423 reproductive aged women, living in urban areas of four selected provinces (Golestan, Hormozgan, Kermanshah and Qazvin), without any hormonal disorder, were enrolled for this study. Clinical examinations, and antropometric, biochemical and hormonal parameters were assessed to determine associations between the hormonal profiles and metabolic syndrome parameters, using Spearman and Pearson correlation tests and Logistic regression. Our analysis revealed that diastolic blood pressure, high density lipoprotein cholesterol, fasting blood sugar and waist circumference were differed significantly between quartiles 1 and 4 of thyroid stimulating hormone concentration. Also, fasting blood sugar and waist circumference differed in the two groups of Sex Hormone Binding Globulin concentration values. Central obesity was associated with reduced Sex Hormone Binding Globulin, a relationship observed after adjustment for age and body mass index. Hormonal variation even with normal limits could be associated with metabolic syndrome parameters and cardiovascular disease, making it necessary to identify individuals in high risk categories.