Preventive and protective effects of garlic juice on histologic alteration in the prostate of streptozotocin induced diabetic rats

Diabetes mellitus has diverse effects on reproductive functions in men, among which are reduction of serum testosterone, seminal fluid volume, and prostate damage. In diabetes the glandular epithelium undergoes shrinkage and becomes cuboidal in shape. The present investigation is aimed to understand the preventive and therapeutic effect of garlic juice on prostate damage in diabetic rats. Forty male wistar rats were divided into 5 groups: 1- Group normal (N) 2- Group Normal+Garlic (N+G) 3- Diabetic (D) STZ (Streptozotocin) injection 60mg/kg BW /ip 4- Group diabetic+garlic before (D+Gb) received garlic juice for 3 weeks before and also 3 weeks after STZ injection. 5- Group diabetic+garlic after (D+Ga) three days after STZ injection, they received garlic juice for 3 weeks. Garlic juice was given by gavage (1ml/100g BW). Diabetes caused regression of prostate, leading to a decrease in its weight. Histologically, glandular epithelium has undergone shrinkage with transformation of acinar cells into low cuboidal type. Rats receiving garlic before STZ injection showed more improvement than those receiving it after injection. In this study for the first time we showed thatadministration of garlic juice could play both preventive and therapeutic role on prostate damage in adult diabetic rats.