مجله دانشکده علوم پزشکی نیشابور
پیاپی 12 (پاییز 1395)

Introduction and Aims In the event of damage to the skin, the epidermis of which goes to the disintegration of the body, is a wound that is common in diabetics. The purpose of this study was to evaluate effect of alcohol extract of curcumin on wound healing in diabetic male rats.
Materials and Methods In this study, 48 male wistar rats were divided into 4 groups of 8 (control (healthy diabetes along with other groups, intraperitoneally as a citrate buffer), Sham (diabetic dose 55mg/kg Streptozotocine and without treatment) experimental 1 (treatment of diabetic eucerin), experimental 2 (treatment of diabetic and alcoholic extract of curcumin ointment). In an area of 3 cm2 dairy tested wounded on the left side of the spine created. The process of healing 14 and 21 days after wounding were examined macroscopically.
Results The later wound healing was reported in streptozocin diabetic compared to the control group and wound healing in experimental groups treated with alcohol extract of curcumin was faster than control.
Conclusion The alcohol extract of curcumin skin accelerate wound healing in normal and diabetic samples.

Introduction and Aims Because of the day-increasing resistance of the bacteria to antibiotics, further logical viewpoint to the medicinal plants seems to be important. The Ferula gummosa considered as a great medicinal plant in past studies. The aim of this study was investigation of aqueous and alcoholic extracts of roots of F.gummosa Boiss on growth of some bacterial pathogens.
Materials and Methods The extracts were prepared by Soxhlet method and were studied by disc diffusion, well diffusion and tube dillution methods.
Results According to the disc diffusion and the well diffusion methods, no inhibitory zone have seen against investigated bacteria. The ethologic extract showed more inhibitory effect than the methanolic and aquatic extracts. The most sensitive bacterium to methanol extract was Staphylococcus aureus with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) equal to 6.25×103 and 1.25×104 respectively. The most sensitive bacteria to ethanol extract were Escherichia coli and Shigella dysenteriae with MIC and MBC equal to 6.25×103 and 2.5×104 respectively.
Conclusion Further study is needed about potent antimicrobial activities of F.gummosa Boiss.

Introduction and Aims Brucellosis is an important disease caused by Brucella species and is a zoonotic disease. Since Iran has focused the majority of livestock in rural areas, the epidemiological studies seems to be necessary in cities with most villages. We aim to survey the brucellosis in suspicious patients who referred to a medical diagnostic laboratory in Neyshabur from 2010 to 2015.
Materials and Methods This study was cross sectional-descriptive. In this epidemiological study, the required information of all patients who were suspected by physicians (2010-2015) was extracted over the last 5 years by laboratory software and the collected data were analyzed by using SPSS.
Results According to Wright’s test, the prevalence of brucellosis was 6.76% in this study. Patients had the titers of 1.80, 1.40 and 1.40 for Wright, 2-Mercapto ethanol (2ME) and Coombs tests respectively. Most participants were in the age group of 41-50 years and 34.1% were male.
Conclusions According to results, Neyshabur has categorized in the areas with high outbreak in the country that should be considered as priorities of local health networks for training and necessary acts.

Introduction and Aims According to high prevalence of cardiovascular diseases, the present study, evaluates the effect of 8 weeks garlic-lemon supplementation on body composition and cardiovascular risk factors in overweight men.
Materials and Methods 20 healthy overweight untrained men (average age=22.37±2.67 years, 86.52±9.88kg and BMI=27.73±2.30kg/m2) were divided in 2 homogeneous group: control group (n=10) and supplementation group (garlic-lemon) (n=10). The first group did not consume any supplement, but the second group consumed lemon-garlic supplement during 8 weeks. Blood sample was collected for measuring HDL, LDL, triglycerides and total cholesterol and general measurements include height, weight, fat percentage, waist to hip ratio and BMI, before and 48 hours after the last training session.
Results Significant decrease in weight (P=0.0001) and fat percentage (P=0.0001) was observed. But there is no significant difference between the muscle mass (P=0.095), as well as waist to hips ratio (P=0.310). After 8 weeks supplementation, HDL increased and total cholesterol levels (P=0.0001) and triglycerides (P=0.0001) decreased, but there was no difference in LDL compared to control group (P=0.544).
Conclusion The present study suggests lemon-garlic supplementation for weight loss and improvement in lipid profile in overweight men.

Introduction and Aims Ruta Graveolens (RG) has been used in various medical preparations for its anti-oxidant, anti-inflammatory, anti-tumour, anti-androgenic and anti-fertility properties. More than 120 natural compounds mainly including acridone alkaloids, coumarines, essential oils, flavonoids, and furoquinolines have been found in the roots and aerial parts of this plant. The aim of this work is to study the anti-fertility propertiese of RG extract. Histochemical studies have been carried out in mouse ovary.
Materials and Methods In this study 36 female mice were used in two groups as control and RG. Control group received the saline normal 0.2 ml and the RG group received 300mg/kg of the aqueous extract of RG per day orally for 14 days. Ovaries were studied after staining ALP, PAS and sudan Black.
Results It was found that in RG group of first week most follicle were atretic. Results indicate that the staining intensity in ALP, PAS and Sudan Black were sever in RG group when compared with the control group. There was no significant difference between the control and RG group after 2 and 3 weeks treatment.
Conclusion RG extract caused metabolic disorder and reduced fertility. This may be due to the increase in the intensity of reaction due to the accumulation of lidids and carbohydrates and damage of intracytoplasmic organels.

Introduction and Aims Iran is a disaster-prone country and this event will be an obstacle to economic and social development. Crisis management and readiness to deal with the crisis in different organizations is essential. The head of these organizations are hospitals, so the aim of this study was to assess the preparedness of Farabi Eye hospital deal with the crisis.
Materials and Methods This cross-sectional descriptive study was performed in Farabi Eye hospital affiliated with Tehran University of Medical Sciences in 2014. Data was collected using a checklist extracted from the book “Hospital Disaster Risk Assessment” which has 5 forms: 1) General information about the hospital 2) Identification of risks 3) Assessment of functional safety 4) Assessment of non-structural safety 5) Assessment of structural safety that completed as self-report and was analyzed using Excel software.
Results Respectively, the most possibility hazards were geological hazards (earthquakes, landslides, and liquefaction), climatic hazards (hurricanes, tornadoes, extreme heat and cold, dust), biological/epidemic hazards (vermin infestation), and human-made hazards (fires, overloaded hospital).
Conclusion According to high losses resulting from accidents, strategic planning of crisis management for health care centers and planning for cooperate health care centers together to deal with the crisis are necessary and it is suggested that training against the crisis is provided to staff of this center and to inform and their participant attraction take the necessary decisions and to be operational.

Introduction and Aims Anxiety has a negative effect on wound healing and tissue repair. Energy expenditure during mental and physical stress of anxiety can lead to prolonged hospital stay and delayed in discharge. One method of reducing anxiety is the use of medicinal plants, in this study efficacy of Nardostachys jatamansi root extract versus oral diazepam on pre-operative anxiety in orthopedic surgery is used.
Materials and Methods This study was a randomized clinical trial on 60 orthopedics patients in Imam Ali hospital of Bojnurd. Patients were divided to two groups 1- valerian (530mg capsules Sedamine) 2-control group. Anxiety (using addition, Berger Anxiety Inventory) and vital signs of patients were measured in orthopedic ward and operating room at the night before and the morning of surgery.
Results The results showed that before intervention, anxiety scores in the intervention group was 46.3±11.9 and in the control group was 50.2±5.0. At this stage there is no significant difference between anxiety scores between the two groups (P=0.30). After the intervention, the mean anxiety score in the intervention group was 36.2±8.9 and in the control group was 46.9±6.1, that there is a significant difference between two groups (P=0.005).
Conclusion Valerian improves patients’ anxiety before surgery, which can be used as a good alternative to anti-anxiety drugs.

Introduction and Aims The aim of the present research is study of validity and reliability of the body Appreciation Scales in Iranian samples. So far, in the assessment of body image that’s been done in Iran were almost exclusively negative aspects of evaluation. The scale used in this study focused on the positive aspects of body image.
Materials and Methods This scale conducted on the sample of 300 undergraduate students studying at Tehran University and Shahed University. Sampling in this study is available sampling.
Results In the present study, Cronbach’s alpha values obtained 0.88, which represented good reliability of this tool in Iran. The results of exploratory factor analysis contains two-factor model, that 12.55% variance of the Body Appreciation Scales was explained. There is a significant negative relationship between positive body image and the body image concern inventory (PConclusion This scale can be used to measure positive body image among Iranian researchers and therapists.