فهرست مطالب

  • Volume:2 Issue:1, 2018
  • تاریخ انتشار: 1397/03/30
  • تعداد عناوین: 5
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  • Faezeh Azizi, Mir Davood Omrani, Mohammad Ali Sadighi Gilani, Jalil Hosseini * Page 1
    Introduction

    Infertility affects an estimated 15% of couples globally and in Iran, a quarter of cou-ples experiences primary infertility. Males are found to be individually responsible for 20-30% of infertility cases and contribute to 50% of cases totally. When assisted reproductive technologies (ARTs) are used to acquire pregnancy, a sufficient (epi) genetic diagnosis of male infertility (MI) is of main matter to consider if a genetic abnormality will be transmit-ted to offspring. Infertility cen-ters together with Infertility research centers had been founded since 1994 in Iran and many arti-cles from research projects have been published.

    Materials and Methods

    This literature investigated the possible genetic causes mechanisms un-derlying Iranian male infertility by extensive article searches. First, we reviewed available data from the Google Scholar, PubMed, Scopus, Web of Science, IranMedex, MEDLIB, IranDoc and Scien-tific Information Database were searched for articles published until 2018, using the MeSH terms for a variety of chromosome abnormalities, Y-chromosome microdeletions, gene mutations, expres-sion and polymorphisms, Male infertility and/or Iranian, regional and international population, to provides the evidence- based and a comprehensive, up-to- date evaluation of the multifactorial fac-tors involved in Iranian infertile men.

    Results

    According to the strategy adopted initially, 274 manuscripts were found. After reviewing the titles, abstracts and manuscripts entirely cited, the total of 139 articles were obtained and se-lected according to the eligibility criteria. The 139 studies were divided into four predetermined categories that mentioned above. Studies have good methodological validity. The sample is quite heterogeneous, given the very different design of the studies.

    Conclusion

    MI is a complex, multi-factorial disease and the underlying reasons frequently remain unknown. It seems that the first line of genetic diagnosis in Iranian male infertility is similar to Global One. In all investigations conducted in Iran, there are vacancies in studies such as epigenetic modification studies, RNA (lncRNA, miRNA and piRNA) abnormalities, mutation detection and pol-ymorphism studies in other genes involved in the spermatogenesis process. At present, we have a little information for some polymorphisms (MTHFR, GST, ER, and DAZL) and mutations (mtDNA, CATSPER) which require more extensive studies. Such articles help to find a better insight into the causes of infertility in the Iranian men's community and will provide valuable visions into the de-velopment of targeted personalized treatments for patients and the ascertainment of the reasons of idiopathic infertility.

    Keywords: Iranian infertile men, chromosome abnormalities, Y-chromosome microdeletions, gene mutations, expression, polymorphisms
  • Alireza Dizavi, Hassan Eini, Zinab *, Jalil Hosseini *, Nasrin Omidvar, Mohammad Ali Hosseini Page 2
    Introduction

    Infertility affects an estimated 15% of couples globally and in Iran, a quarter of In-troduction: One of the current debates regarding men’s reproductive health is the declining sperm count and the role of nutritional and environmental factors. This study aims to investigate the asso-ciation between dairy product consumption and oligozoospermia, sperm count of 5 to 15 million per milliliter of semen, in adult men.

    Materials and Methods

    This age-matched case-control study was conducted on 102 oligozoo-spermia and 306 healthy men (control group). Both groups were recruited from an infertility clinic in Tehran, the Royan Institute. Dietary intake of subjects was collected using a valid and reliable 168-item food frequency questionnaire. Odds ratios (OR), ex-tracted from conditional logistic re-gression, were used to compare the occurrence of oligozoospermia by tertiles of dairy intake.

    Results

    After adjusting for potential confounding variables, the high intake of low-fat dairy prod-ucts was inversely associated with the risk of oligozoospermia (OR: 0.48; 95%CI: 0.24 – 0.95), (P =0.046). The higher intake of high–fat dairy products [(OR: 2.44; 95%CI: 1.26 – 4.73), (P =0.008)], high–fat milk [(OR: 2.16; 95%CI: 1.09 – 4.30), (P =0.043)], and ice creams [(OR: 2.37; 95%CI: 1.25 – 4.50), (P =0.008)] were also positively associated with oligozo-ospermia.

    Conclusion

    The high intake of low–fat dairy foods seems to have a protective effect on oligozoo-spermia. Higher intake of high – fat dairy products, high– fat milk, and ice creams were associated with an increased risk of oligozo-ospermia.

    Keywords: Oligozoospermia, low sperm count, dairy, low fat dairy
  • Mohammad Ali Sadighi Gilani *, Hesamoddin Sajadi Page 3
    Introduction

    Bilateral vassal agenesis (CBAVD) is a rare cause of male infertility. Also one of the
    nonobstructive cause of azoospermia and infertility in men is microdeletion in long arm of Y chromosome.
    In this case report we have reported a rare case of CBAVD, LT renal agenesis and AZFc
    microdeletion.

    Patient Information:

    28 years old man, who was farmer with history of 6 years of infertility presented to our andrology
    clinic in Royan institute. In physical examination there was not any palpable vas deferens bilaterally,
    also The semen analysis was azoospermia. In sonographic evaluation, LT kidney wasn’t seen in
    its anatomic location. The patient candidate for diagnostic PESA and bilateral PESA were negative.
    After that, the patient candidate for bilateral TESE and fascinatingly TESE was negative too. After
    genetic evaluation microdeletion was detected in AZFc subregion of Y chromosome.

    Conclusion

    In men with obstructive azoospermia mostly testicular spermatogenesis is normal but this is not
    the rule because seldom spermatogenic dysfunction maybe present like our patient. We emphasize
    about the importance of consideration of obstructive and nonobstructive azoospermia together in
    a patient for urologists.

    Keywords: Vassal Agenesis, Azoospermia, Azoospermic FactorCite this article
  • Ali Zare, Mirzaie, Fazele Soltani Shirazi, Afshin Moradi, Zahra Vejdani, Mohammad Taghi Haghi Ashtiani, Behrang Kazeminezhad * Page 4
    Introduction

    Male factor infertility is the cause of 20 to 30% of infertile couples in population, and there are reports that obesity in men may be one of the factors affecting fertility. Accordingly, this study aimed to examine the relationship between Body Mass Index (BMI) and semen parameters in 20 to 50 year-old Iranian men.

    Materials and Methods

    The archives of two major laboratories in Tehran were screened and the results of semen analyses from 640 nonvasectomized men referring during 2009-2013 were col-lected. Data on height, weight, BMI, age, sperm count, percentage of sperm motility, normal sperm morphology, and sperm viability was recorded. Anal-ysis of these data was performed using SPSS software.

    Results

    The mean age of subjects and their mean BMI were 30.2 ± 5.9 years and 26.0 ± 4.1 kg/m2, respectively. The average values of semen parameters were as follows: total sperm count = 53.7 ± 33.6 million, pH = 8.2 ± 0.3, normal sperm morphology = 50.1 ± 10.9%, viability = 69.46 ± 12.6%, and grade-A sperms = 39.4 ± 16.8%. BMI had no significant correlation with the semen parameters including sperm morphology, viability, pH, and motility.

    Conclusion

    No significant correlation between BMI and semen parameters was observed in the sample of Iranian males evaluated in this study.

    Keywords: Body Mass Index, Semen Analysis, Sperm Count
  • Masoumeh Mohammadi, Jalil Hosseini *, Morteza Fallah Karkan, Mehdi Hedayati Page 5
    Background

    Adipokines play a role in pathogenesis and progression of certain cancers. Resistin is an adipokine with diverse findings in disease development and progression. The present study aimed to determine Resistin serum levels in bladder cancer cases in order to identify novel tumor markers.

    Methods

    This research was based on a case-control study, including 45 patients with bladder can-cer and 45 healthy controls. Resistin levels were measured by ELISA in both groups. Height and weight were measured and body mass index (kg/m2) was calculated.

    Results

    Resistin levels were significantly different between bladder cancer and the control group (p<0.0001) but Resistin levels in different stages were not significantly different. Also there was no correlation among sex, age, body mass index and the serum Resistin levels.

    Conclusion

    These results suggest that changes in serum Resistin levels play an important role in the diagnosis and could act as a biomarkers for bladder cancer.

    Keywords: Cluster Resistin, Bladder Cancer, Biomarker, Adipokine