Journal of Skin and Stem Cell
Volume:5 Issue: 3, Sep 2018

Treatment of some fungi species would result in the improvement of atopic eczema.

In this study, the anti-Malassezia IgE in patients with atopic eczema before and after treatment with a ketoconazole shampoo was determined.

In this before-after investigation, 20 consecutive patients with atopic dermatitis referring to a teaching hospital in Tehran, Iran, in 2015 were enrolled. A ketoconazole shampoo was administered two times a week each time for 5 - 10 minutes. The treatment was used for two months and monthly evaluations were done. The total IgE level and anti-Malassezia IgE were compared at the beginning and the end of the study.

The results demonstrated that there was a statistically significant difference in the total Ig-E level and anti-Malassezia IgE before and after treatment with ketoconazole.

According to the obtained results in this study, it may be concluded that ketoconazole would result in decreased anti-Malassezia IgE and total IgE level in patients with atopic eczema

Role of insulin-like growth factor 1 (IGF1) and contributing cancer risk has been shown in many studies. Hence, this study was performed to determine the serum level of IGF-1 in patients with acne vulgaris in comparison with healthy subjects.

The current study was a case-control assessment performed on a sample of 102 subjects, including 51 known cases of acne and 51 healthy subjects (without acne as controls). Serum IGF-1 level was assessed and compared across the two groups.

Both groups were matched for age and gender (P > 0.05). The mean IGF-1 level was significantly (P = 0.0001) higher in the case group. There was a significant reverse correlation between age and serum IGF-1 level (P = 0.002, r = -0.417). Also, the mean serum IGF-1 level was significantly higher in males compared with females in the case group (P = 0.006). The severity and location of acne had no association with serum IGF-1 level (P > 0.05).

Overall, according to the obtained results in this study, it may be concluded that rate of metabolism is increased in patients with acne. This finding suggests that nutrition-related lifestyle factors play a role in acne pathogenesis. Hence, modifications in these styles are recommended to control acne formation. Also, use of IGF-1-reducing drugs, such as metformin, may be useful for treatment of acne. However, this matter may be confirmed by future studies