مجله دانشکده پزشکی اصفهان
پیاپی 608 (هفته چهارم اسفند 1399)

Psoriasis is a kind of common, chronic, and exacerbating skin diseases. It does not have any certain treatment but it can be controlled. Different treatments have been used to control the disease, from positional steroids in mild cases to methotrexate in severe cases, all of which have multiple side effects. The aim of the present study was to investigate the effects of Florabile, derived from Iranian Traditional Medicine, on reducing the severity of psoriasis rashes.

In a semi-experimental study, 25 patients aged 20 to 50 years with mild to moderate psoriasis and patients whose bodies were involved below than 20 percent were participated for a 30-days experimental period. They diluted Florabile syrup containing three spoons (each spoon with an approximate volume of 15 cc) with a glass of water (250 cc), and consumed one hour before lunch daily. Results were scored using the Psoriasis Area Severity Index (PASI) at the beginning and at the end of the study, and then evaluated by two dermatologists.

Consuming the medicine meaningfully reduced inflammation of the rashes, scaling, plaque, percentage of involvement, and PASI score (P < 0.050).

Findings show significant positive effect of Florabile syrup on reducing the severity of psoriasis rashes.

In this study, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anti-epidermal growth factor receptor antibody (anti-EGFR-SPIONs) were used as a targeted contrast agent in magnetic resonance imaging (MRI) in mice.

This was an experimental intervention, performed on 25 C57BL/6 healthy and cancerous mice on LL/2 (LLC1) cell line. Atomis absorption spectrophotometry (AAS) was used to determine of iron content in tumor and other studied tissues and MRI scanner was applied for MR imaging signal intensity under in-vivo conditions.

The results of AAS showed a good iron uptake using specific antibody in the tumor compared to other organs. Moreover, image signal intensity findings revealed its targeted diagnosis for lung cancer LLC1 cells.

Designed nanoprobes may be used as a diagnostic agent in detection of target cells and as a contrast agent for targeted magnetic resonance imaging of these cells.

The colorectal cancer (CRC) is one of the most common cancers. There are several invasive and noninvasive methods for detecting CRC. Diagnosis based on the molecular markers in early stages seems to be a good choice. The aim of present study was evaluating the methylation in GRASP gen promoter in colorectal cancer tissue compared with healthy surrounding tissue.

This cross-sectional study was performed on 50 patients suffered from CRC during 2016-2019. The DNA was extracted from 50 Formalin-Fixed Paraffin-Embedded (FFPE) samples of CRC tissues in early stages (I and II), and normal surrounding tissues. In paraffin method, methylation-quantification of endonuclease-resistant DNA was calculated, and their frequency were compared in both groups.

GRASP gene’s promoter was highly methylated in patients with CRC in early stages compared to their normal margins. GRASP gen promoter methylation was 70.47% (P < 0.00001) in CRC tissue compared with 38.08% in normal margin (P < 0.0001).

The results showed that frequency of Grasp gen’s promoter methylation in colorectal cancerous tissue was significantly more than normal surrounding tissue.