مجله دانشگاه علوم پزشکی گرگان
سال بیست و چهارم شماره 1 (پیاپی 81، بهار 1401)

The scientific evidence related to the effectiveness of rehabilitation on electromyographical activity of trunk muscles is limited. This study was performed to determine the effect of movement-pattern training on frequency of selected trunk muscles during single-leg landing in individuals with non-specific chronic low back pain.

In this clinical trial study, 28 patients with non-specific chronic low back pain were randomly divided into intervention and control groups. The control group did not receive treatment. The intervention group performed treatment as a movement-pattern training. Subjects performed single leg landing from 30 cm height. Trunk muscle activity was assessed using an 8-chanel EMG system. The assessments were completed in pre-test and after six weeks.

Frequency content of right rectus abdominus and right lumbar erector spinae in intervention group were lower than control group (P<0.05). In other muscles ant there was not any significant significant differences between interventional and control groups.

The movement-pattern training can be used in rehabilitation of individuals with non-specific chronic low back pain.

Sedentary life and vitamin D deficiency are considered as related factors to increased inflammation and oxidative stress in obese individuals. This study was performed to determine the effect of Pilates training with vitamin D supplement on Monocyte chemoattractant protein-1(MCP-1) level and superoxide dismutase (SOD) activity in overweight men.

In this single-blind clinical trial, 56 overweight men were randomly assigned to control, Pilates, vitamin D and combination groups. The Pilates training was performed for 8 weeks with the intensity of 50-75% of reserve heart rate, 3sessions/week. The vitamin D and combination groups received 50,000 units of vitamin D per week. The levels of MCP1 and SOD activity were in the first and 8 weeks after interventions.

Vitamin D status in subjects was lower than normal level. MCP-1 level in Pilates, vitamin D and combination groups significantly reduced and SOD activity increased after 8 weeks (P<0.05), but the combined intervention had a stronger effect on the modulation of MCP-1 level and SOD activity compared to the other two interventional groups (P<0.05). In addition, the effect of Pilates exercises on increasing SOD activity was more than vitamin D intake (P<0.05).

It seems that Pilates training and Vitamin D intake can be exert their protective effects in overweight individuals with abnormal vitamin D status by an increase on the SOD activity and decreasing the inflammatory index of MCP-1. Although these effects developed with combined intervention, Pilate training was associated with greater increases in antioxidant levels than vitamin D.

Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Propofol in patients Undergoing surgery.

In this double-blind randomized clinical trial study, 80 patients aged 18 to 65 years were randomly blocked and assigned into four groups including Lidocaine, Ketamine, Magnesium Sulfate and Normal Saline. The pain was measured with the Ambesh Score. Hemodynamic changes of patients were evaluated in 1, 3, and 5 minutes.

The patients in Lidocaine, Ketamine, and Magnesium Sulfate groups with 75%, 70%, and 55%, respectively, did not feel pain after Propofol injection compared to Normal Saline group (25%) (P<0.05). The mean time trend of Systolic and diastolic blood pressure and mean arterial blood pressure between the studied groups were significant (P<0.05).

The use of Lidocaine or Ketamine during Propofol injection can be effective in reducing pain during injection in patients undergo surgery.

Fibromyalgia syndrome is a chronic disease with extensive musculoskeletal pain that primarily involves women and also it has negatively effects on many aspects of psychological and social life. Cognitive-behavioral therapy examines dysfunctional emotions and maladaptive cognitive behaviors, processes, and themes, and cognitive-behavioral hypnotherapy combines hypnotherapy with the methods and concepts of cognitive-behavioral therapy. The aim of this study was to compare the effectiveness of cognitive-behavioral therapy with cognitive-behavioral hypnotherapy on sexual satisfaction of women with fibromyalgia syndrome.

This clinical trial study was done on 9 women with fibromyalgia syndrome who referred to rheumatology clinic in Gorgan, northern Iran in 2020. The patients were randomly divided into three groups including cognitive-behavioral therapy, combination cognitive-behavioral hypnotherapy and control group. The treatments used were performed for 8 sessions separately for 2 groups of 3 people in Pars Tavan Comprehensive Center. Control group did not receive any intervention. A multidimensional sexual satisfaction questionnaire of Roshan 2014 was used to evaluate patients.

Sexual satisfaction in post-test on both interventional group showed a significant improvement compared to control group (P<0.05). Cognitive-behavioral hypnotherapy with 59.38% was more effective than cognitive-behavioral therapy with 43.01 and also it was the same 2 month after follow up (P<0.05).

Combined therapy of cognitive-behavioral hypnotherapy increased sexual satisfaction in women with fibromyalgia syndrome more than cognitive-behavioral therapy.

Sphingosine-1-phosphate (S1P) plays an important role in muscle biology and is involved in hypertrophy and activation of satellite cells. This study was done to determine the effect of eight weeks of concurrent training with different order on S1P in fast and slow muscles in wistar rats.

In this experimental study, 40 male wistar rats (weight 180-200 gr) were randomly allocated into 5 groups including control, resistance training, endurance training, resistance- endurance training, endurance- resistance training. Resistance training consisted 1-meter ladder climbing with the loading of percent of overloading test (%75 of weight body) in the first week and increased to 30 gr per week. Endurance training consisted of running on treadmill with speed of 12 m/min and 10 minutes in the first week to 30 m/min and 60 minutes in the last week. The resistance- endurance group performed resistance training 5 minutes before endurance training and the endurance- resistance group performed endurance training 5 minutes after resistance training. The protein level of S1P was measured in flexor hallucis longus (FHL) and soleus muscles.

The S1P level in fast and slow twitch muscle increased significantly in endurance- resistance training, resistance- endurance training and resistance training compared to controls (P<0.05). There were no significant differences between concurrent training with differing order.

It seems that exercise order in concurrent training result in no different effect on S1P level in fast and slow twitch muscles in wistar rats.

Type 1 diabetes (T1D) is highly prevalent in the group of autoimmune and inflammatory patients. Tumor necrosis factor-alpha (TNF-a) and interleukin-10 (IL-10) plays an important role in regulating complex interactions between pancreatic beta cells and immune cells in the development of T1D. This study was performed to determine the simultaneous effect of resistance training and endothelial progenitor cell injection on blood glucose levels and protein expression of proinflammatory factors TNF-a and IL-10 in muscle tissue of streptozotocin (STZ) induced diabetic male rats.

In this experimental study, 36 male Wistar rats weighing approximately 200±20 g and six weeks old were randomly divided into six groups. Induction of diabetes was performed by intraperitoneal injection of STZ at a dose of 45 mg/kg body weight. Groups included diabetes + stem cell injection + resistance training group, diabetes + resistance training group, diabetes + stem cell injection group, control diabetic group to control the passage of time, and healthy basal and diabetic groups for defaults. Exercises were performed for 17 sessions of resistance training, including climbing ladders with increasing weight three days a week in the same laboratory conditions. Endothelial progenitor cells were cultured by femoral bone marrow aspiration and culture and then injection into the tail vein. 68 hours after the last training session, blood glucose levels were assessed by ELISA and the expression of TNF-a and IL-10 protein in muscle tissue was assessed by Western blotting.

Endothelial stem cell injection, resistance training and resistance training with the simultaneous injection of endothelial stem cells significantly increased the anti-inflammatory factor IL-10 in the skeletal muscle tissue of diabetic rats in compared to control group (P<0.05). Expression of the anti-inflammatory factor IL-10 in the skeletal muscle tissue was significantly increased in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05). Glucose concentration in the skeletal muscle tissue was significantly reduced in resistance training plus the simultaneous injection of endothelial stem cells group in compared to injection of stem cells and resistance training groups (P<0.05).

It seems that 17 sessions of resistance training reduces blood glucose level and improves inflammatory conditions in response to an increase in IL-10 and a decrease in TNF-a in a group of diabetic rats with resistance training and simultaneous injection of endothelial progenitor cells in diabetic male rats.

Back pain is a common orthopedic disease that affects up to 80% of the population at some point in life. Brace is one of the tools that used to reduce pain. The relationship between brace application and gait parameters in people with low back pain is not well understood. This study was done to determine the effects of simple and sensor thoracolumbosacral braces on gait kinetics in patients with low back pain.

This quasi-experimental study was performed on 15 men and women with low back pain in the biomechanics laboratory of Mohaghegh Ardabili University Health Center in nort-west of Iran during 2020. Each participant performed three gait conditions including without brace, with sensory brace and with simple brace. Ground reaction forces were recorded and compared by a force plate while walking.

The average walking speed during no brace, simple brace and sensor braces were not significant different. Also, results did not demonstrate any significant effect of simple or sensor braces on ground reaction force amplitudes, their time to peak, and free moment values.

Simple and sensory thoracolumbosacral brace did not effect on gait kinetics in low back patients.

Infertility is one of the issues that affect many aspects of infertile couples. In this study current infertility in Tehran province is estimated based on clinical, epidemiological and demographic definitions.

This descriptive-analytical study was performed on 669 women with a spouse aged 15-49 in Tehran, Iran during 2020. Data were collected by using a valid researcher-made questionnaire.

Prevalence of current infertility by clinical, epidemiological and demographic definitions was 9.6%, 8.1% and 5.8%, respectively. As expected, primary infertility is lower (2%-4%) than secondary infertility (1.8%-6.4%). Some couples become infertile after their first pregnancy and the birth of their first child. Infertility has a significant relationship with age (P<0.05), age in the first marriage (P<0.05) and socio-economic statuse (P<0.05).

Current primary infertility is relatively low and normal, but secondary infertility is high. Focus on lifetime infertility shows higher rates of infertility than current infertility in Tehran, Iran.

Iron deficiency anemia lead to a decrease in intelegence question (IQ) and a decrease in learning and mental and physical abilities. This study was done to determine the status of iron intake in infants aged 6 to 24 months under the cover of comprehensive health centers in Miandorood city, Mazandaran province, Iran during 2019.

This descriptive-analytical study was carried out on 400 infants aged 6-24 months who were enrolled in comprehensive health centers in Miandorood city, Mazandaran province, Iran during 2019. The status of iron drop consumption and mothers' awareness in this field were evaluated.

The mean age of the infants was 13.8±4.8 months. The range of the mother’s age was 28.8±5.6 years. Of these, 274 (68.5%) of infants used iron drops regularly, 106 case (26.5%) often, and 20 case (5.0%) never. The mother's knowledge score was significantly correlated with the type of iron intake, height percentile, and maternal education level (P<0.05). Evaluation of the possible causes of irregular iron intake shows that the most frequent cases were forgetting (28.8%), 9.5% for nausea and vomiting, and ‎‎9.0% for teeth color changing.‎

Mothers' awareness of iron drops consumption was good. The most important barriers to regular iron intake in the present study were forgetfulness, vomiting, and tooth discoloration.

Inflammatory bowel disease (IBD) is a common gastrointestinal disease which is associated with psychosocial factors. IBD is a gastrointestinal disease with chronic recurrence and with an uncontrolled immune response. There is no definitive treatment for IBD and treatment is based on management of inflammatory response during relapse and maintain of recovery. This study was conducted for evaluation of anxiety and depression disorders in patients with IBD in Golestan province, north of Iran during 2017.

In this descriptive-analytical study, 117 patients (67 women and 50 men) aged 17-75 years with IBD registered in IBD bank in Golestan Research Center of Gastroenterology& Hepatology (GRCGH), north of Iran during 2017. Diagnosis was made by conventional endoscopy, radiology and histological criteria. Demographic information including age, sex, race and marital status, time of diagnosis until now and duration of treatment are recorded. Hospital anxiety and depression scale (HADS) were used for determine depression and anxiety in these patients.

80.3% ulcerative colitis and 19.7% Crohn's disease was observed in patients. The mean of total anxiety score in the group with Crohn's disease was higher than ulcerative colitis but there was no significant difference. Total score of depression was similar and not significant in both groups. There was a significant statistical relationship between marital status and anxiety in patients with ulcerative colitis only (P<0.05). As borderline and suspicious status of the patient in married patients is 42.4% and in single patients is 33.3%. Abnormal anxiety state was 31.8% in married patients and not seen in single patients. A positive and significant correlation was seen between total anxiety scale and total depression scale in patients with ulcerative colitis (correlation index: 0.657, P<0.0001) and in patients with Crohn's disease (correlation index: 0.644, P<0.001). Therefore in these patients, if depression increases, anxiety was also increasd. Anxiety observed in 29.8% and 26.1% of ulcerative colitis and Crohn's disease, respectively. Depression disorders observed in 18.1% and 8.7% of ulcerative colitis and Crohn's disease, respectively.

This study showed that the level of anxiety and depression in patients with inflammatory disease is very high.

Near to 30% of women experience some type of anxiety disorder in their life, which this anxiety occurs more often in pregnancy and after delivery. Maternal anxiety reduces secretion of oxytocin and lactation. On the other side, the level of maternal stress and anxiety increasingly increases the incidence of postpartum. This study was carried out to evaluate the prevalence of postpartum anxiety in Gorgan north of Iran during 2018.

This descriptive-analytical study was performed on 154 women between 15-45 years old and it has passed at least one week to maximum six weeks since their delivery whom referred to obstetrics clinic of Shahid Sayyad Shirazi hospital in Gorgan, North of Iran during 2018. Demographic check list was used to collect the demographic. Data and Spielberg anxiety scale was used to measure anxiety.

Anxiety disorders after childbirth was 41.99%. The overt anxiety score of postpartum women in severe, moderate, mild and little or none level was 8.4%, 44.2%, 27.9%, 19.5%, respectively. The hidden anxiety score of postpartum women in severe, moderate, mild and little or none level was 9.7%, 48.1%, 24.7%, 17.5%, respectively. The overt anxiety score in employee mothers was significantly higher than housewive mothers (P<0.05). The overt anxiety score in women with marital discord was significantly higher than in women without marital discord (P<0.05). Ther was not significant relationship beween overt and hidden anxiety score with the type of delivery, mother's education, mother's residency and familial income.

The prevalency of postpartum anxiety disorders was high in this region and it was related to job and marital discord.

Having a proper diet is very important. Many risk factors are involved in the development of cardiovascular disease that by changing them, the incidence of this disease can be reduced. This study was performed to determine the relationship between nutritional knowledge and level of physical activity with the prevalence of metabolic syndrome and some cardiovascular risk factors in militaries men.

This descriptive-analytical study was performed on 97 athletes and non-athletes militaries men. The standard Parmenter and Wardle Nutrition Knowledge Questionnaire of 1999 and Baecke Physical Activity Questionnaire were completed. Subjects' fitness scores and physical indicators were measured. Prevalence of metabolic syndrome, based on revised ATP ш and IDF was calculated.

The mean nutritional knowledge of the subjects was moderate to low. There was a significant correlation between the nutritional knowledge, level of physical activity and fitness score and cardiovascular risk factors (P<0.05). Also there was a significant correlation between the nutritional knowledge, level of physical activity and fitness score with preventing metabolic syndrome (P<0.05).

With increasing nutritional knowledge, physical activity and fitness scores the risk of cardiovascular factors reduces and the possibility of metabolic syndrome prevention increase.

Yersinia is water and foodborne organism that cause human gastroenteritis. This study was done to evaluate the frequency of Yersinia species isolated from children diarrheal samples and chicken meat in Tehran, Iran.

In this descriptive study 250 sample of diarrhea of children referred to the Children's Medical Center, Tehran, Iran and 250 samples of chicken were collected and examined for Yersinia infection during July 2016 to March 2017. Isolation method was performed based on initial enrichment in phosphate buffer for 3 weeks in refrigerator (cooling in c4 +) and then using KOH as secondary enrichment and culture on CIN agar medium. Biotyping method was used to determine pathogenic strains.

In this study, 5(2%) isolates from pediatric diarrhea samples and 20 isolates (8%) from chicken meat samples were obtained from Yersiniaenterocolitica. Biotyping of human Yersiniaenterocolitica isolates identified 3 cases of biotype 1A, one case of biotype 1B, one case of biotype 2 and from chicken meat isolates, 16 isolates belonged to biotype 1A and 4 isolates belonged to biotype 1B.

Presence of common pathogenic 1B and non-pathogenic 1A biotypes in pediatric diarrhea samples and chicken meat can indicate the cause of diarrhea in children.

Kawasaki disease is a medium-size vasculitis with peak incidence among infants of 9 to 11 month age. This case report represents a female infant of 18-month age whom was admitted to the Taleghani Pediatric Center of Gorgan, Iran; with referral for admission due to persistent fever for roughly 2 weeks despite various outpatient treatments. Upon the admission, Echocardiographic study was performed to assess whether the patient fulfils cardiac criteria of Kawaski disease which was consistent with the diagnosis and also positive for serious coronary complications in the infant. General condition of the patient improved as the treatment with both IVIG and Corticosteroids was initiated and carditis seemed to vanish in echocardiographic studies but as expected aneurysmal growth can last for over 80 days and in this case serial echocardiographic studies confirmed the formation of giant coronary aneurysms. Diagnosis of Kawasaki disease is based on persistent fever and consistency with clinical criteria and the main purpose of this case report was to emphasize the need to consider this disease in cases of persistent fever to avoid the serious following complications.