Journal of Current Oncology and Medical Sciences
Volume:2 Issue: 3, Summer 2022

Warburg effect is a form of cellular metabolism commonly used by cancer cells, in which, consumption of glucose and production of acidic cell metabolic wastes take place at a considerably higher rate. The effect is well described in the literature, however, the applications for cancer prevention and treatment have not been resolved effectively yet. According to the Warburg effect, anaerobic cellular respiration and the resulting acidic cellular environment are linked to the development of cancerous tumors. But an oxygen-rich environment with optimum alkalinity at the cellular level can result in retaining healthy cells and inhibiting cancer cell growth. As an alternative or complementary solution for cancer treatment based on the Warburg effect, a healthy balanced diet with alkalizing (but not alkaline) properties helps maintain acid-base balance in the body and also provides optimum metabolic rate and sufficient hydration for more effective health improvement. This paper presents a review of the key concepts related to links between cancer and dietary and environmental factors, with the main focus on the Warburg effect and energy metabolisms in cancer cells. In addition, some practical diet-based solutions are summarized that may potentially control cancer by utilizing the reversed Warburg effect by which, optimum pH levels and sufficient oxygenation may be provided at the cellular level.

The risk factors for the metallothionein (MT) polymorphism in concentrations of heavy metals, especially mercury, in the blood are subject to several confounding factors, including differences in the ethnicity of the population analyzed, the sample size, and the type of the studied environment heavy metals to which population is exposed. This study aimed to investigate the effects of the MT1A (A>G) and MT1A (C>G) single nucleotide polymorphisms (SNPs) on blood mercury levels in the city of Ahvaz (located in southwest Iran).

300 unexposed (control group) and 150 exposed (case group) were included. DNA extraction, PCR-RFLP and DNA sequencing were performed, and blood mercury levels were determined by AAS method with DMA-80.

Blood mercury levels in the case group were higher than those in the control group (p-value <0>G), with MT1A (C>G) polymorphism and P-values ​​of blood mercury levels of 0.69, 0.44, and 0.59. 0.56 for the case and control groups, respectively. Results showed that these two SNPs were not associated with mercury-induced toxicity in the case group despite high blood mercury levels and exposure.

In conclusion, this takes look shows that MT1A (A>G) and MT1A (C>G) polymorphisms aren't related to susceptibility to excessive blood mercury attention in individuals.

Mental health problems and personality disorders may influence individuals’ motivation to request cosmetic surgeries. The aim of this study was to assess mental health status and personality disorders among the candidates for rhinoplasty.

This case-control study was conducted in 2019–2020. Participants were 45 candidates for rhinoplasty and 45 individuals with no request for rhinoplasty purposefully selected from the ear nose throat clinics of Ruhani hospital, Babol, Iran. Data collection instruments were the Symptom Checklist-90 Revised (SCL-90-R) and the Millon Clinical Multiaxial Inventory (MCMI). The SPSS software (v. 16.0) was employed for data analysis through the independent-sample t and the Chi-square tests at a significance level of less than 0.05.

In the case group, 28.9% of participants had at least one psychiatric symptom and 7.26% had at least one personality disorder. The prevalence of psychiatric symptoms and personality disorders in the case group was significantly more than in the control group (P < 0.05).

Compared with individuals with no request for rhinoplasty, the prevalence of psychiatric symptoms and personality disorders is high among the candidates for rhinoplasty. Therefore, a preoperative mental health assessment is essential to improve post-rhinoplasty outcomes.

Since December 2019, COVID-19 has caused a pandemic. The use of effective and safe complementary therapies can be helpful in COVID-19 treatment. Traditional Persian medicine (TPM) is a kind of traditional medicine based on more than a thousand years of Persian medical practice. The purpose of this research is to introduce TPM opinion for the study of COVID-19 pathophysiology.

TPM literature was searched during centuries 4th to 13th AH, using these keywords: “Havaye vabaii” and “Homayat”; Databases (PubMed, PMC, Google Scholar, and Scopus) were also searched by: “fever”, “cough” “dyspnea”, etiology, pathophysiology of COVID-19. This research has been done in seven phases.

According to TPM resources, the human body is comprised of four primary elements: earth, water, fire, and air, and their combination makes humors (Khelt) and temperaments (qualities). The ingested food undergoes four stages of digestion to produce four humors in body including blood, phlegm, yellow bile, and black bile. The balance of four humors is effective in health maintenance. Persian Medicine physicians believe, that all diseases can be prevented and cured by modification and avoidance of etiologic factors. We tried to explain, that humors change in exposure to Coronavirus due to hepatic dysfunction and based on TPM texts.

According to the results of the present research, some methods for effective prevention and treatment suggestions for COVID-19 can be proposed in the context of Persian medicine and based on the opinion of Persian medical scholars.

Acetaminophen poisoning is one of the most common types of suicide in Iran. Investigation and identification of factors affecting the severity of this poisoning can have a significant impact on optimal treatment management. The aim of this study was to evaluate the clinical findings of Acetaminophen poisoning and its associated factors.

In a cross-sectional study, the files of patients admitted due to acetaminophen poisoning in the years 2011-2015 in the poisoning ward of Razi Educational Center in Rasht have been reviewed. Demographic characteristics of the poisoned, acetaminophen use, number of days of hospitalization, poisoning outcome, history of addiction, previous suicide history, time spent from drug use to hospitalization, clinical findings, severity of poisoning and laboratory test results were extracted from patients' records and registration. Independent t-test, chi-square and regression analysis were used to investigate the relationship between study variables and severity of intoxication.

In this study, 244 cases of poisoning were investigated. The highest frequency of symptoms was related to nausea (25.9%) and then vomiting (22.1%). More than 99% of those poisoned recovered. Mean hospital stay (P = 0.015), mean hospital stay after acetaminophen (P = 0.001) and mean liver enzyme levels (P < 0.05) were significantly higher in the moderate to severe intoxication group compared to the asymptomatic group. In the logistic regression analysis, even after removing confounders, there was a statistically significant association between the duration of the patient's arrival at the hospital (P <0.001, OR = 15.44; 95% CI: 5.88- 40.44) and the amount of acetaminophen consumption (P <0.001, OR = 4.62; 95% CI: 2.00- 10.68) with severe poisoning.

In this study, most of those poisoned were female and aged 21-30 years. Most of the poisoned recovered. The acetaminophen dose and the duration of drug intake until hospitalization were significantly associated with the severity of poisoning and the mean values of liver function tests were higher in the high poisoning group.

In Persian medicine (PM) references, the bathroom is not only important for body cleanliness. In this study, the applications and therapeutic effects of taking a bath are investigated.

This is a library study that searched the keywords of bath, taking a bath, and washing in the comprehensive traditional medicine library of Noor research center, PubMed, Google Scholar, and SID databases as well as other domestic and foreign articles.

From the PM’s point of view, taking a bath has many privileges and it is recommended for maintaining the health of normal people and the treatment of diseases in patients. The sages of Persian Medicine have written many papers about the benefits of bathing and therapeutic solutions in bath such as bathtubs, oil therapy, massage, and use of hot, cold, and mild types of baths. They have referred to various types of water in this treatment. In general, they have discussed the preventive and therapeutic uses of bathing such as relieving pain, anxiety, DM, enhancing sleep quality, and promoting the quality of life in cancer patients. Bath is not only a place for body cleansing, which is predominant in modern baths. In addition to the role of their architecture based on temperament, these are prescribed to prevent the disease and due to their therapeutic effects.

From the point of view of PM, baths with different and appropriate conditions can have many applications for maintaining the health status of normal people or the patient's treatment and recovery.

Aluminum phosphide (AlP) is a significant fumigant and a notable, highly effective pesticide for both indoor and outdoor use. Analytical tests like the gas chromatographic method in post-mortem specimens and survivors have been developed to assess the quantity of phosphine and to differentiate between ZnP and AlP poisoning, even if clinical history can usually aid in making the final diagnosis. In this way, it is demonstrated that mitochondrial failure caused ALP to create reactive oxygen species (ROS). As a result of red blood cell hemolysis, decreased ATP synthesis, and the activation of apoptosis in cardiomyocytes brought on by ROS generation, different problems eventually develop. Since cardiomyocytes are the cells that are most significantly affected by ALP, using the right therapeutic methods to get the cells working again will prolong patient survival. Correspondingly, Phosphine's ability to inhibit cytochrome c oxidase has been demonstrated in vitro. It seems improbable that this interaction is the main driver of its toxicity, though. ALP poisoning may cause the most damage to the mitochondria, which might lead to poor ATP synthesis, metabolic shutdown, and multiorgan dysfunction (MOD). Additionally, due to an impairment in electron flow, there may be free radical formation and damage, which could also result in MOD. Rats and insects have shown signs of ALP-induced toxicity brought on by reactive oxygen species. A similar mechanism might potentially be present in people and help fill in the gap in the pathophysiology of ALP poisoning. Cellular poisoning, oxidative stress, cholinesterase inhibition, circulatory failure, cardiotoxicity, gastrointestinal and pulmonary toxicity, hepatic damage, neurological toxicity, electrolyte imbalance, and general metabolic disturbances are just a few of the many effects caused by metal phosphides. In this review article, we discuss the association of cytotoxicity, mitochondrial damage, and oxidative stress by Aluminum phosphide.