مجله دانشکده پزشکی اصفهان
پیاپی 697 (هفته اول بهمن 1401)

Pruritus is a common problem in people with chronic kidney disease undergoing hemodialysis. Itching can greatly affect the quality of life. There is no widely used and agreed-upon treatment for pruritus associated with end-stage renal disease (ESRD). Fumaria parviflora L is a medicinal plant with several medicinal properties, including outstanding anti-inflammatory activity. The aim of this study was to compare the Effect of Fumaria Parviflora and Gabapentin in the Treatment of Uremic Pruritus in Hemodialysis Patients.

A total of 52 hemodialysis patients with pruritus were randomly divided into two groups receiving Fumaria Parviflora or gabapentin. One group was given 1500 mg of Fumaria Parviflora once a day for two months and the second group was given gabapentin 300 mg three times a week after dialysis for two months. Patients' pruritus scores were assessed before and after the intervention in two groups.

This study showed that pruritus in the two groups before the intervention was not significantly different. Both gabapentin and Fumaria Parviflora significantly reduced pruritus in hemodialysis patients after the intervention. There was no significant difference between the two groups in the severity of pruritus after the intervention.

The results of this study showed that both gabapentin and Fumaria Parviflora significantly reduced the rate of pruritus in hemodialysis patients. The results of this study showed that Fumaria Parviflora as a safe herbal medicine was as effective as gabapentin in reducing pruritus in uremic patients.

THQ is one of the key tools for psychiatrists to diagnose and study the PTSD. Unfortunately, there is no standard sample of it in Persian, so the aim of this study was to evaluate the validity and reliability of the Trauma History Questionnaire in non-psychotic psychiatric patients.

This was a cross-sectional study. The final Persian translation of THQ was given to 5 psychiatrists and psychologists to evaluate the reliability and content validity of each item of the questionnaire and then according to the inclusion and exclusion criteria, eligible patients were included in the study. Fifty non-psychotic psychiatric patients were used to determine the construct validity between THQ and SLESQ questionnaires. They also completed the PCL and DASS checklists.

According to the findings of present study, it was seen a significant correlation between THQ and SLESQ. Cronbach's alpha coefficient of the whole questionnaire was 0.704. Regarding the answer to the questions, the experience of each type of trauma in 23 cases, the kappa statistics showed excellent reliability (above 0.6) and in 10 cases showed complete correlation of test and retest answers. Reliability was not very good for the experience of natural disasters (κ = 0.540). To evaluate the heuristic factor structure, the value of Kaiser-Meyer-Olkin index was sufficient for the adequacy of sample size 0.617 and Bertlett's sphericity test was statistically significant.

The results of this study showed that THQ has good validity, retest reliability and internal stability and its factor structure was satisfactory.

This study was performed to evaluate the effect of chlorogenic acid (CGA) on spermatogenesis in ionizing irradiated (IR) mice.

In this experimental study, 45 mice were divided into 3 equal groups including group 1 (normal saline), group 2 (IR + normal saline), and group 3 (IR + 5, 10, 20, 40, and 80 mg/kg CGA). After 35 days, the histomorphometry of testicular tissue, cells count in different developmental stages, viability of sperms and finally, fertilization capacity was evaluated. Data were analyzed by ANOVA one-way analysis of variance and post hoc Turkey’s tests.

The results showed that testicular weight, germinal layer thickness and diameter of seminiferous tubules in the IR group were significantly different from the sham and IR + CGA (40 mg/kg) groups. In addition, in the IR group, the number of spermatogonia cells, primary spermatocytes, spermatid and Leydig cells were significantly decreased compared to the sham group. These changes were significantly ameliorated in the IR + CGA (40 mg/kg) group and histological studies did not show any tissue damage. At the same time, the number of germ cells, the thickness of the epithelium of the seminiferous tubules and the diameter of the seminiferous tubules didn’t showe significantly difference with the sham group.

The present study shows that CGA (40 mg/kg) can be beneficial against the harmful effects of X-ray exposure by improving histopathological changes in the testis.