فهرست مطالب

Researcher Bulletin of Medical Sciences
Volume:27 Issue: 1, Sep 2023

  • تاریخ انتشار: 1402/04/07
  • تعداد عناوین: 14
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  • Morteza Gholipour, HamidReza Aslani, Sona Bonakdar Page 1
    Objective

    As the prevalence of the coronavirus increases, there is now more emphasis on reducing "face-to-face" patient visits. Therefore, the use of smartphones and their special medical applications can play an important role in following up patients. The aim of this study was to evaluate the use of smartphone in evaluating clinical outcomes and range of motion of patients after elbow operation.

    Materials and Methods

    Forty patients were randomly selected from patients undergoing elbow operation. Patients were divided into two groups, so that in the first group, the patients were visited and then were followed-up for 2,6, and 12 weeks as well as 6 months after first visit by smartphone connection and delivering the pictures and videos of involved organ to the physician as well as having the physical examination him. In the second group, all assessments were performed by clinical visiting at the same time points.

    Results

    The two groups were similar in baseline characteristics including demographics; the side of involved elbow, type of fracture, surgical approach, operation time, and mean Mepi score. Assessing the postoperative complications and also patients' satisfaction was also similar in both groups. There was no difference in different range of elbow motion degrees between the case and control groups at different times of following-up as well as the progress in motion of elbow after surgery in two groups. Moreover, there was no significant difference between the range of motion evaluated by smartphone and physical examination.

    Conclusion

    The use of the smartphone has a high degree of accuracy and sensitivity in assessing the status of elbow range of motion after surgical treatment, both in the short and long term after surgery.

    Keywords: Smartphone, COVID-19, Pandemic, Range of motion, Elbow joint
  • Narges Gholami, Fariba Farnaghi, Hassan Pourmoshtagh, Mitra Radfar, AliAsghar Halimi Asl, Fatemeh Fereshteh Mehregan, Latif Gachkar Page 2
    Objective

    The severe acute respiratory syndrome coronavirus 2(SARS COV 2) is an important health problem, which is widespread around the world. This study describes the characteristics of COVID-19 infections in healthcare workers (HCWs), related factors and deaths in Non- COVID pediatrics departments from the early phases of COVID-19 pandemic; February 20th, 2020toJanuary19th, 2021 in Tehran-Iran.

    Materials and Methods

    It is a multi-center cross-sectional descriptive study. The standardized questionnaire was designed according Demographics information, Coronavirus disease (COVID-19) history in HCW and Using and access to Personal Protective Equipment (PPE). All data analysis was performed by SPSS software version 21.

    Results

    Of the 82 HCW, 67 (81.7%) was female. The median age was 37.6 ±10.3 years old (rang 24 to 65). 44 (53.6%) were nurses, 14 (17 %) pediatrics residents,13 (15.9%) pediatrics faculty members,8(9.8%) environmental services staff and 3(3.7%) secretaries. Twelve out of our cases (14.6%) have underlying medical diseases. Thirty-six (42.7%) confirmed COVID19. In COVID-19 positive group 28(80%) were female. Among whom 51.4% were identified nurses, 17% faculty member and14.3% pediatrics residents. Secretaries and environmental services staff are more vulnerable job category in this study. Eighty-six percent of them follow protective health protocol and use PPE. COVID-19 cases were infected more on July 2020(25.7%), November 2020 (17.1%) and August 2020(14.2%).

    Conclusion

    Approximately one half of HCWs in non-Covid-19 pediatrics department infected with corona virus 2 (SARS_COV_2) and most of them thought they were infected in workplace.

    Keywords: COVID-19, Pediatric, Healthcare worker
  • Mohammad Hassani, Mehdi Tavallaei, Parynaz Parhizgar, Peyman Bakhshaei Shahrbababki Page 3
    Introduction

     Gastrointestinal stromal tumor (GIST) is a rare mesenchymal tumor of the gastrointestinal (GI) tract that usually occurs in the stomach and the small intestine, respectively. This tumor often occurs in people over the age of 40 years, especially in the fifth and sixth decades of life. The range of symptoms varies from asymptomatic to symptomatic depending on the size and location of the tumor. The standard diagnostic of this tumor is the pathological examination of tissue specimens. Also today, the main treatment for this tumor is surgery and resection of the tumor. 

    Case Report:

     A 43-year-old woman presented with melena and a decrease in hemoglobin level to 4. The patient underwent upper and lower GI endoscopy, CT angiography, and EUS, which was reported a vascular lesion below the ampulla of vater. After laparotomy and Whipple procedure, pathology reported tumor as GIST. The patient was discharged from the hospital in good general condition. 

    Conclusion

     we suggest that patients presented with gastrointestinal bleeding and the presence of a lesion in the diagnostic modalities, GIST should always be considered as a differential diagnosis.

    Keywords: Gastrointestinal stromal tumor, GIST, Gastrointestinal bleeding
  • Ahmad Sheibani Nia Page 4
    Background and Objectives

    Given the extensive number of surgical procedures available for correcting CL III anomalies, the present study was conducted in a private clinic from 2014-15 to determine whether simpler orthodontic and surgery techniques could be an alternative to the conventional techniques for resolving such functional and aesthetic problems.

    Materials and Methods

    The present study was conducted using a sequential before-after design on patients with mild to moderate maxillary deficiency. First, the study records including casts, photographs and radiographs were prepared. A Hyrax appliance with two tongue plates was then constructed for the patient before the Surgically Assisted Rapid Maxillary Expansion (SARME) osteotomy. The surgical technique involved local anesthesia without general anesthesia and the Lefort I osteotomy was performed without down fracture and without the manipulation of the pterygomaxillary suture. The transverse problem was corrected by unscrewing the Hyrax, and the tongue force exerted on the back of the tongue plate corrected the sagittal maxillary deficiency. To evaluate the efficacy of this appliance, the mean changes to the cephalometric indicators before and after the treatment were examined, and the paired t-test was used for the statistical analysis.

    Results

    The present study was conducted on 11 patients (9 females and 2 males). The mean changes indicated a significant increase in Articular Angle, Jarabak index, and a significant decrease in L1 - NB (mm), L1 - NB (º) and Saddle Angle. The other indicators had either decreased or were not changed.

    Conclusion

    Using a Hyrax appliance combined with a tongue plate after a SARME surgery is effective in correcting CL III anomalies associated with maxillary deficiency.

    Keywords: Malocclusion, CL III, Maxillary deficiency, SARME, Tongue plate, Hyrax
  • Mehdi Mojarrad, Nosrat Riahinia, Ali Azimi, Parisa Amiri, Farzad Hadaegh Page 5
    Background & Objective

    Doctor-patient relationship plays an important role in adherence of patients to treatment instructions. This study tries to examine the relationship between physicians and patients with type 2 diabetes in the treatment process by the grounded theory.

    Materials and Methods

    Eleven physicians and 9 diabetic patients in both sexes were selected from among all type 2 diabetic patients referred to physicians' offices in Shahid Beheshti University of Medical Sciences and Health Services. A semi-designed interview was used to gather information.

    Results

    The factor influencing the physician's lived experiences in dealing with the patient and the patient's lived experiences in dealing with the physician was named as the "physician-patient discourse" factor. This factor included 9 categories in 2 central codes "physician-centered" and "patient-centered" in the physician's lived experiences with the patient and 4 categories in 2 central codes "awareness" and "confidence-building" in the patient's lived experiences in dealing with the physician.

    Conclusion

    A discourse in which the physician allocates adequate time to efficiently convey training and information, and to take a complete history of the patient, and to establish an effective, friendly, and respectful relationship ultimately lead to the patient's trust. These factors can persuade the patient to adherence to the prescribed treatment.

    Keywords: Grounded theory physician, Diabetes, Health education, Self-care
  • Fariba Ghorbani, Shadi Shafaghi, Sima Noorali, Guitti Pourdowlat Page 6

    One of the most important concerns during the covid-19 pandemic is an imbalance in health services. Considering significant mortality among hospital staff and the general population, a great apprehension was raised in society. Consequently, many patients with symptoms were rushed to hospitals. In this regard, to keeping clinics away from overcrowding, call interview with patients plays a crucial role in not only patients screening but also treatment approach.

    Keywords: Call interview, Health services, Isolation, Telemedicine
  • Reza Bidaki, Hamideh Noshadifar, Najmeh Shahini, Zanireh Salimi Page 7
    Background & Objective

    Cancer is a global concern, and the management of cancer patients dealing with various psychological symptoms is a growing concern. Acceptance and commitment therapy (ACT) is effective psychological management in cancer patients improving psychological symptoms. However, the effect of ACT on cancer patients' resilience and general health has not been widely studied. The present study aimed to evaluate the effect of ACT on the general health and resilience of cancer patients undergoing chemotherapy.

    Materials and Methods

    Sixty patients with breast, lung, or colorectal cancer enrolled in the present study and allocated into intervention and control groups. The Connor-Davidson Resilience Scale (CD-RISC) and General health questionnaire (GHQ) were filled as pretest and post-test after ACT as eight sessions (each session 9') during four weeks for the intervention group and after 4-weeks for the control group.

    Results

    The mean age of the participants was 35±76.3 years, and the mean age, gender, cancer duration, duration of receiving chemotherapy, and marital status were not significantly different among the study groups. After adjusting for baseline scores, there was a significant difference in study groups in resilience and general health scores. The effects indicate that treatment accounted for 70.9% and 62.6% of the post-test covariance of resilience and general health scores, respectively.

    Conclusion

    ACT could be an effective psychological intervention in increasing general health and resilience among cancer patients.

    Keywords: Resilience, Cancer, General health
  • Elaheh Aghaei, Arezoo Alaee Page 8
  • Mojtaba Zonoobi, Shaban Elahi, Mohammad Khansari, Alireza Hassanzadeh, Tahereh Sahib Page 9
    Objective

    With the introduction of digital crypto currency, the worth of data has been obvious to everybody. Of course, this research is in the sphere of medicine. The goal of this research is to perform a comprehensive evaluation of studies in the area of health information system data sharing and secondary uses of health data, with the goal of generating value in multiple dimensions by sharing these data.

    Material & Methods

     The researchers used the intelligent Web of science and IEEE search engines to conduct a systematic evaluation of English-language keyword searches. Two tactics have been studied in this respect, one using keywords related to "health data value" and the other using terms linked to "health data sharing."

    Results

     Although several studies have suggested solutions for decreasing obstacles to health information system data sharing, they have often simply addressed the problem, according to one criticism of the papers examined. The sharing barrier has no remedy, and its relevance is simply emphasized.

    Conclusion

     It was discovered that not all of the successful components of data sharing, particularly data from health information systems, were addressed in the evaluated studies.

    Keywords: Health data, Data value, Data value creation, Data sharing
  • Minoo Pargol, Shohreh Zare Karizi, Morteza Karimipoor Page 10
    Objective

    Long non-coding RNAs (lncRNAs) are characterized as non-coding transcripts greater than 200 nucleotides. lncRNAs have extensive molecular connections with proteins and microRNAs, which are important in the regulation of gene expression in physiologic and pathologic states including cancer. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs play key roles in the progression and metastasis of NSCLC. In this study we evaluated the expression of long non-coding RNAs: GHET1, BACE1-AS, PANDA, UCA1 in non-small cell lung cancer.

    Material & Methods

    In this study, RNA was extracted from tumor tissues of NSCLC and paired adjacent normal lung tissues. After cDNA synthesis, the relative expression level of lncRNA GHET1, BACE1-AS, PANDA, and UCA1 genes was studied by TaqMan Real-Time PCR, and the data were analyzed by 2-∆∆CT. The t-test was used to compare the values and P-value < 0.05 was considered statistically significant.

    Results

    The data of qRT-PCR analysis revealed that the expression level of GHET1 gene in patients with NSCLC is increased (P= 0.0032) and BACE1-AS showed down-regulation (P= 0.0093). There was no significant change in the expression of PANDA and UCA1 genes.

    Conclusion

    Our study sheds lights on the expression signature of several crucial lncRNAs in human lung cancer. This data not only could be further be utilized for different therapeutic approaches but also reveal the changes in biological processes of human lung tumors.

    Keywords: BACE1, GHET1, lncRNA, Lung cancer, PANDA
  • Maryam Taherkhani, Mohammad Ghasemi, Adine Taherkhani Page 11
    Objective

    Recognition of probable risk factors for cardiovascular disease is crucial in non-CAD patients for preventive programming. The purpose was determination of 10-year cardiovascular disease (CVD) among patients without current cardiovascular disease.

    Material & Methods

    In this observational study that was performed as a diagnostic survey, 606 consecutive patients without current cardiovascular disease, referring to Modarres and Loghman Hospitals, Tehran, Iran in 2017 and 2018 were enrolled and ASCVD plus score determined the 10-year cardiovascular disease among them.

    Results

    The results in this study demonstrated that mean ASCVD plus score was 13.1 ± 14.9 points. Among cases 284 (40.9%), 67 (11.1%), 154 (25.4%), and 137 (22.6%) patients were in groups 1, 2, 3, and 4, respectively. The mean risk was higher in men, diabetics, smoker, users of anti-hypertensive, statins, and aspirin, older, with higher blood pressure, and also with higher total and LDL cholesterols.

    Conclusion

    Totally, according to the obtained results in current study, it may be concluded that 10-year risk of cardiovascular disease is relatively high among patients without current cardiovascular disease. This matter shows the importance of routine screening in such population.

    Keywords: CVD, Risk, General population
  • Mojdeh Jahantigh Jahantigh, Mohaddeseh Larypoor Page 12

    One of the most important problems from the past to the present is deadly opportunistic disease in developing countries, which leads to increase mortality in the world. Microbial pathogens such as fungi, bacteria, parasites, and viruses can cause these deadly opportunistic infections. Herbal medicines in the form of nanoparticles, nanocapsules, and biocompatible polymers, and liposomes can be effective in reducing mortality from these infections. Also due to the excessive use of antibiotics, microbial resistance is expanding day to day. On the other hand, indigenous, cheapness, availability, and rich source of effective herbal substances have made these compounds have many applications in biomedical fields. The aqueous extract, essential oil, and active ingredients of various parts of plants such as bark, stems, leaves, fruits, and seeds are used in the treatment of infectious diseases. This article provides information about medicinal plants that have antibacterial properties and are used to treat microbial infections. It is hoped that using this method can reduce and treat microbial infections to some extent.

    Keywords: Medicine plants, Microbial infections, Biopolymers, Nanocapsules, Nanoparticles
  • Amin Momeni Moghaddam, Pooneh Dehghan, Naser Vallaei, Hadi Majidi, Seyyed Hasan Langari Page 13
    Background

     The frequent use of brain computed tomography (CT) scans in emergency settings necessitates accurate reporting of CT results as quickly as possible. Conventional CT scans produce grayscale images, requiring window width and center level changes, resulting in a need for time-consuming interpretation by experienced radiologists. This study aimed to design a novel software application for automatic smart colorization of conventional brain CT images and to evaluate the diagnostic accuracy, visual quality, ease of diagnosis, and reporting time for color CT images compared to conventional grayscale CT images.

    Materials and Methods

     First, we designed an application that converted non-enhanced grayscale brain CT images into color images according to the Hounsfield unit value of different tissues (e.g., brain, fat, bone, fluid, air) with minimal noise so that all brain tissues could be evaluated using one window level. This process took less than one second, without the need for high-end systems. Next, 75 printed images (25 unprocessed grayscale CT, 25 processed color CT, and 25 magnetic resonance imaging [MRI]) from 25 patients with hemorrhagic or ischemic stroke were read by two experienced radiologists. The radiologists scored the CT images from each patient (unprocessed grayscale and processed color) on a ten-point scale for visual quality and ease of diagnosis compared to the MRI image.

    Results

     The mean visual quality score was 18% higher and the mean ease of diagnosis score was 23% higher for colorized images than for grayscale images (both P < 0.001). Statistically, there were no significant differences in the diagnostic accuracy or reporting time between color and grayscale images.

    Conclusion

     This is the first study to report automatic smart colorization of non-enhanced brain CT images, producing high-quality colorized images with better visual quality and ease of diagnosis compared to grayscale CT. This low-cost solution can be widely applied in clinical settings, regardless of minimal facility or resource availability.

    Keywords: Acute stroke, Automatic data processing, Image enhancement, Software design
  • Asal Omidsalar, Shahin Emami Meibodi, Ferena Sayar, Ahmad SheibaniNia Page 14
    Background and Objective

     Periodontal problems are very common among patients undergoing fixed orthodontics treatment. Using mouthwashes such as Listerine and Persica is recommended in order to prevent such complications. There have, however, been no information on the comparative effects of Listerine and Persica mouthwashes so far. Thus the comparative study presented here under the title of “Evaluating the comparative effects of Listerine Zero and Persica Mouthwashes on the Periodontal Conditions of fixed orthodontics Patients was conducted at the Department of Dentistry of Azad University of Tehran.

    Materials and Methods

     A blind randomized clinical trial was conducted on 30 patients. All subjects were between 20 and 50 years of age; had been under fixed orthodontic treatment for at least two months; did not have serious systemic health complications; had a minimum of 5 teeth in each quadrant for evaluation. Root planning and scaling were conducted on male and female subjects prior to their entry into the study. The SI, GI, PI, and BOP indices of each subject were then recorded in the base-line stage. The subjects were then divided into two random groups. The first group was treated with Persica (Pursina Co., Iran) and the second group with Listerine Zero (Johnson & Johnson, New Jersey, USA). The two groups were followed up twice after two and four weeks of treatment and their SI, GI, PI, and BOP indices were recorded.

    Results

     The SI, GI, PI, and BOP indices were found to have changed by similar amounts in both groups (P<0.12). The changes in GI, PI, and BOP were, however, statistically significant within each group (P<0.02). The changes in SI index within the Persica group were found to increase only within the first two weeks of treatment (P<0.05).

    Conclusion

     Following the comparative study described above, both mouthwashes appear to positively affect the periodontal condition of fixed orthodontics patients. Both mouthwashes were, however, found to have similar effects.

    Keywords: Listerine, Persica, Periodontal diseases, Fixed orthodontics