Eurasian Chemical Communications
Volume:5 Issue: 8, Aug 2023

The aim of the present study was to extract of Polyalthia sclerophylla leave (LPS) and identify its chemical constituents using Gas chromatography-Mass (GS-Mass) spectrometry and classical phytochemicals methods. This study included as well the evaluated of the bio-medical properties of LPS using antibacterial (against six bacteria species) and cytotoxicity (M-63 human cell line) activities. Three different solvent system i.e. methanol (MeOH), dichloromethane (DCM) and hexane were used to extract the LPS, three samples were obtained and labelled as MLPS, DLPS, and HLPS, respectively, and evaluated their biomedical activities. Phytochemical screening results showed to present glycosides and terpenoids in MLPS, DLPS, and HLPS, while alkaloids did not detect the presence in all extracts. GC-Mass results were detected to present 21 chemical compounds, the higher percentages were cyclobutanone, 2-methyl-2-oxiranyl-, 2-Undecanol and Pyridine, 2,3,4,5-tetrahydro-3-methyl-, while 1,6-Heptadiene, 1,1,3-Trimethylcyclopentane, and 2(5H)-Furanone, 5-methyl were detected to be presented with low percentages. Alamar blue assay was used to evaluate the LPS cytotoxicity and there was no-toxic effect for all concentrations with higher cell availability average 99.5 %. MLPS, DLPS, and HLPS were showed significant effect to inhibition the bacteria growth, MLPS showed more effect than DLPS and HLPS to be used as a bacterial agent. Current study was establishment for chemical and biomedical properties of LPS and showed good biomedical properties with non-toxic effect.

The present work includes preparing new compounds of 1, 2, 3-Triazole, and Tetrazole based on Cromoglicic Acid and using them as anti-bacterial and ant-oxidant agents. The mentioned compounds were prepared using click chemistry; triazole rings were reacted with azide (terminal alkyne of cromoglicic acid) in the presence of copper as a catalyst. The modified compounds were characterized using different techniques such as FTIR, 1H-NMR, and 13C-NMR. Then, the antioxidant and antibacterial activities of the synthesized compounds were experimentally examined in vitro versus two kinds of bacteria (Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria)).The DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical method was used to measure the antioxidant activity of the prepared compounds, while the antibacterial activity was examined using the diffusion method. The obtained results for all prepared compounds were good as an antioxidant in comparison with ascorbic acid.

There is an urgent need in the medical community today for the discovery of anti-carcinogenic and anti-oxidative medicines that are more effective and have fewer adverse effects. To accomplish this goal, novel chalcone compounds (A1–A6) were produced by subjecting the Duff formylated mephenesin (I) and substituted aromatic ketones to a Claisen-Schmidt condensation reaction. Through the use of well-established spectroscopical techniques, the basic chemical structures of the produced derivatives were deduced. The MTT assay was used to determine how effective the produced chalcone derivatives were in vitro as neoplastic inhibitory agents against five different malignant cell lines, including HepG2, A549, MCF-7, HeLa, and Ovcar-3. In a similar manner, the anti-oxidative impact of chalcone derivatives was examined in vitro by making use of the DPPH moiety. According to the data, the derivative with the potent electronegative substituent, A2, exhibited the most potent anti-neoplastic impact compared to the other derivatives, with 50% inhibitory concentration (IC50) values that were quite near to those of the gold standard (doxorubicin). This effect was shown especially in relation to the HepG2 and A549 cells. In addition, the derivative A2 showed that it had a significant antioxidative impact on the examined free radical moieties, with percentage inhibition (Pi) values that were close to those of the standard (ascorbic acid).

In this work, chalcones were synthesized by condensing ketone containing azo dye with aromatic aldehyde derivative (Vanillin) at room temperature and in a diluted ethanolic potassium hydroxide solution. The subsequent reaction of chalcone with urea, thiourea, hydrazine hydrate, and hydroxylamine hydrochloride led to the synthesis of novel heterocyclic derivatives including oxazine, thiazine, pyrazol, and isoxazole, respectively. After that, the effect of these compounds was studied on gram-positive (Staphylococcus Epiderimidis, pseudomonas, and gram-negative (Klebsiella pneumoniae and E.Coli) bacteria. The (FTIR, 1H-NMR, and 13C-NMR) spectroscopies were used to characterize each of the synthesized compounds.

Tissue engineering benefits from electrospun scaffolds, particularly as drug carriers and reconstructive materials for orthopedic implants, as well as many other uses obtaining a large number of publications in a short period in the region through the production of complex scaffolds, the development of new nanotechnology processes, and improvement of imaging methods. Labeling these materials has become critical to achieving accurate and satisfactory results. This is an excellent method for mimicking the extracellular matrix of bone using biodegradable and biocompatible polymers for bone restoration. In this project, electrospinning of a PMMA: PVA scaffold is used. These composite fibers had a clear and continuous shape when examined under a scanning electron microscope (SEM), and their components were identified using (FTIR). Experiments revealed that this characterization of significant effects in the electrospinning method for biomedical applications plays an important role in producing implant coating materials for bone reconstruction.

In medical chemistry, aminoqunoline-7-hydroxylic acid is considered as a very useful and attractive nucleus supporting compound. Since then, it has become a central moiety in a variety of bioactive compounds. We synthesised new antioxidants from 6-aminoqunoline-7-hydroxylic acids and determined their antioxidant activity. In cellular and intracellular physiological responses, the peptides are usually considered as the main regulators and widely expected to be used in disease treatment. Due to their therapeutic significance, the two vital molecules, aminoqunolines and peptide derivatives have been combined together into a single molecule by changing the various amino acids synthesized by different chemical reactions. Analysis and valdation of such compunds by Fourier transform infrared (FTIR), 13C and (1H) nuclear magnetic resonance (NMR) spectra was done. The specific optical rotation (SOR) has also been determined. The evaluation of in vitro antioxidant activities of such multifunctional compounds was carried out using the DPPH and Nitric oxide free radical scavenging methods. Activity was noted for derivatives from 6-aminoqunoline-7-hydroxylic acid, while other members showed a higher antioxidant activities than the ascorbic acid. All the five compounds synthesized were studied for their potent antioxdinat activity. A2 and A3 showed highest DPPH scavenging activity at 4 µM. Activity was increased for A3 upto 63.3% and 66.8% on increasing the alkyl chains and polar side chains respctively. A1 was found to exhibit high nitric oxide scavenging activity with 31.2% of activity. This study confirmed the synthesis of new compounds through infrared and NMR spectra. Moreover, they are highly effective in scavenging free radicals.

In this article, a Schiff base ligand was produced with Co (II) and Ni (II) complexes. The Schiff base was prepared by the condensation reaction between 9,10-phenanthrynquinone and 2-mercaptoaniline in a ratio of 1:1, respectively, and the reaction time was  three hours. While the Co (II) and Ni (II) complexes were prepared by reacting the prepared Schiff base ligand with the metal chloride salts in ethanol also in 1:1 molar ratio of L:M and the synthesis time 12 hours. The produced ligand was characterized by infrared spectroscopy, UV-Vis, 1H-MNR, mass spectroscopy, and thermal gravimetric analysis, while the complexes were also characterized by UV-Vis spectroscopy, FTIR, conductivity measurements, atomic absorption, magnetic susceptibility, and thermal gravimetric analysis. The resulted complexes were green in color. Based on the results, the coordination between the metal ions and the Schiff base occurs through the imine group of the Schiff base ligand, the thione group and the remaining oxygen atom of 9,10-phenanthrynquinone. While the conductivity test shows that the two complexes are non-electrolyte in nature where ethanol was used as a solvent. The magnetic susceptibility values of Co and Ni (II) complexes were found to be 3.09 and 3.3 7 BM, respectively which indicate the presence of three unpaired electrons and two unpaired electrons in both complexes, respectively. These values also support the octahedral geometry of the higher spin complexes and confirm the sp3d2 metal hybridization in the complexes. The atomic absorption values of the complexes and the thermogravimetric analysis confirm that the proposed structure for the complexes is [M(L)ClH2O)]XH2O.

In this study, we synthesized a series of new Schiff base derivatives containing adamantane moiety in the skeleton structure using adamantanol as the initial material, the adamantanol undergoes two reaction steps. In the first step, adamantanol reacts with acetanilide to produce 1,3-bis(4-acetamido-1-phenyl)adamantane as a salt. In the second step, the produced salt prepared in first step undergoes de-protection reaction by react with aqueous solution of sodium hydroxide to generate 1,3-bis (4-amino-phenyl)adamantane. This amine derivative reacts with different aromatic aldehydes to synthesis Schiff base derivatives of adamantane, as well as characterization of hybrid compounds by FT-IR, Mass spectroscopy, 1H-NMR, 13C-NMR, and study of antioxidant   activity. All synthesized derivatives have good scavenging ability against (2,2 diphenyl-1-picrylhydrazyl) free radical, at the range of 81.4-89.9% at high concentration of 1 mg/mL.