مجله طب جنوب
سال بیست و ششم شماره 1 (فروردین و اردیبهشت 1402)

The WDR79 gene encodes an antisense RNA which it is essential for stabilization and in-duction of p53 gene. WDR79 gene Single nucleotide polymorphisms are associated with cancer risk. This study was done to assess the association of WDR79 (rs2287497C>T) gene polymorphism with the risk and prognosis of breast cancer in women’s of northwest Iran.

In this case-control study, the association of WDR79 (rs2287497C>T) gene pol-ymorphism with breast cancer susceptibility was studied in a statistical population consisting of 100 pa-tients and 100 healthy controls aged 19-76 years old by Tetra ARMS-PCR. Statistical analysis was per-formed using javastat online statistics package and SPSS V.26.

In the case group, the frequency of CC, TT, and TC genotypes were 76, 21, 3 percent respective-ly and they were 80, 18, and 2 percent for the control group. Also, C and T allele frequency in case group, was 86.5 and 13.5 percent and those in the control group were 89 and 11 percent respectively. Statistical analysis showed non-significant association between genotype and allele frequency and breast cancer. Also our results showed significant association between age and tumor size of patients with breast cancer in Northwestern Iran.

These research findings suggest that WDR79 (rs2287497C>T) polymorphism of rs2287497C/T is not related to the risk of breast cancer. There was significant relationship between this SNP polymorphism and pathological characteristic including age and tumor size.

The protozoan Cryptosporidium is an intestinal pathogenic parasite; are more common in hot climates and places where water and sewage treatment is less effective. The aim of this study was to detect Cryptosporidium in raw urban wastewaters entering the Bushehr coastal area. 

In total, 48 samples of urban raw wastewater samples were collected from 8 stations in winter and summer seasones. Wastewater samples were filtered through a 300 μm sieve to re-move large particles and then on a cellulose acetate membrane with a pore size of 1.2 μm. The filters were scraped and washed with 40 ml of phosphate buffered saline (PBS) containing 0.05% TWEEN and then centrifuged at 5000 rpm for 10 min at 4°C. The freeze-thaw cycles cycles were used for DNA extraction. The level of extracted DNA was measured by NanoDrop (Spectrophotometer, ND1000), and PCR prod-ucts were separated by electrophoresis in 2% agarose gel.

PCR analysis showed out of the 48 samples, 17 samples (35.4%) werepositive PCR amplification by nested PCR in the case of Cryptosporidium spp. In total, 11 and 6 samples were positive in the winter and summer seasons, respectively. 

Local authorities should be aware of probable cryptosporidiosis epidemics between the residents by paying attention to wastewater treatment processes and suitable preventive measures will help reduce the transmission of human and animal cryptosporidiosis.

Planetary health is a concept that denotes the human health is connected with Earth’s natu-ral systems and they are not separable from each other. Planetary health indicates for the importance of Earth’s natural systems in terms of averted cases of disease and the potential harm that arises from human-caused perturbations of these systems.

In order to evaluate the perspective of medical students of Bushehr University of Medical Sciences about planetary health in relation to medical profession, the method of focus group discussion (FGD) was used. Four sessions of FGDs with participation of 21 medical student were de-signed. The level of their knowledge on climate change and its relationship with human health (the first goal), the scope of physicians’ duty in connection with planetary health, and how to introduce this duty to medical students (the second goal) were the keystones of the FDG sessions.

The medical students were thoroughly aware of climate change and its impacts on environment via the media and their personal experiments. They also had a high level of knowledge about the close relation of human-caused perturbations with human health. The majority of participants believed that the attention to bioenvironmental challenges should be among the ethical and organizational duty of the future physicians. The use of attractive and multimedia approaches in association with field work were emphasized to improve the level of medical students’ knowledge about topics of planetary health.

It is possible to integrate planetary health educations into the medical curricula by avoid-ance of traditional methods and turning to innovative and creative approaches in the format of interdisci-plinary and field works. Hence, the future physicians will attain a sufficient level of knowledge in order to combat with human-caused climate perturbations.

Oral health in elderly people affects the choice of type of food consumed, physical and psychological condition of the person and their social communication and is of great importance. Considering the importance of issues related to oral health and cognitive impairments in the elderly, this study was conducted with the aim of investigating the relationship between oral health and cognitive impairments in the elderly of Bushehr city in 1400.

This descriptive study was conducted in 1400 on 120 elderly people who were selected based on stratified sampling from comprehensive health centers in Bushehr city. Data were collected using demographic information form, cognitive impairment test (CIT-6) and "Oral and Dental Health Assessment Index" (GOHAI) and then analyzed using frequency tables, descriptive statistics including mean and standard deviation, correlation test and regression model at a significance level of 0.05

Most of the study participants (60.8%) were men. The mean age of the subjects was 64.88±4.16 years and most of them (81.6%) were retired or unemployed. The mean score of oral health was 42.49±6.06 and the mean score of cognitive disorder was 9.06±2.45. The statistical results showed that there is an inverse and significant relationship between oral and dental health and cognitive disorder of the elderly that with increasing oral health status, the cognitive impairment of the elderly decreases (r=-0.267, P-value= 0.003).

the health team including dentists, nurses and doctors can understand the importance of the issue of oral health of the elderly and the complications caused by Educate about the level of hygiene and ask the personnel and staff of health services to take this issue into consideration in their patient edu-cation programs.

The similar efficacy of rivaroxaban and warfarin in thromboembolic events was recognized in clinical trials. But there are a few studies about the comparison of these medications in real world. This study was designed with the aim of comparing the efficacy and safety of the rivaroxaban and warfarin.

All patients who received rivaroxaban or warfarin during April 2019 and October 2020 were recruited in the study. The major bleeding and thromboembolic events were considered as primary outcomes. Secondary outcomes were all cause mortality and minor bleeding. All of patients were followed for six months after recruitment and the end of study.

Of 242 patients recruited during the 18 months, 116 patients received rivaroxaban and 126 received warfarin. There were no significant differences between warfarin and rivaroxaban regarding major bleeding (p=0.24) and thromboembolic events (p=0.38). The minor bleeding was significantly higher in warfarin group. (29.36% versus 12.93%, p=0.002). The all-cause mortality rate was similar between two groups (p=0.67). More than 12% of patients were discontinued rivaroxaban, due to high cost. In warfarin group, 14.28% patients did not have compliance due to laboratory fluctuations and inappropriate access to medication.

In the present study, warfarin and rivaroxaban had similar efficacy and safety. In addition, suitable compliance was observed in both groups.

 Sexual function can be affected by hormonal changes, and recent studies indicate changes in the serum level of adipokines after childbirth. The present study aimed to investigate the relationship between sexual function after birth, the type of delivery, and the serum concentration of omentin-1.

 This prospective cohort study was conducted in 89 women who were in the third trimester of pregnancy and met the inclusion criteria. The mother's serum omentin-1 concentration was measured in the first 24 hours after delivery, and its relationship with postpartum sexual function was evaluated according to the effect of delivery type.

 The results of the analysis showed that there was no significant relationship between sexual function and the type of delivery (P≥0.05). Also, serum levels of omentin-1 in the first 24 hours after vaginal delivery were higher than cesarean, but this relationship was not significant (P= 0.948). The results of Pearson's correlation test, between the serum level of oemantin-1 and sexual function in the vaginal delivery group showed that omentin-1 has a significant and inverse relationship with sexual function in the third trimester of pregnancy and the 12th week postpartum. (Respectively r= -0.317, p= 0.034 and r= -0.327, p= 0.028).

 The results of the present study showed that the type of delivery had no significant relationship with sexual function. Also, the serum level of omentin-1 in the first 24 hours was higher in vaginal delivery than in cesarean. It can be concluded that the higher level of omentin-1 in mothers with vaginal delivery may act as a protective factor against metabolic disorders.