Journal of Kermanshah University of Medical Sciences
Volume:18 Issue: 2, 2014

uterine leiomyoma is the most common benign pelvic tumor in women of reproductive age and is frequently associated with abnormal uterine bleeding and pelvic pressure. Combined therapy of gonadotropin-releasing hormone analogue (GnRH-a) and selective estrogen receptor inhibitors (raloxifene) reduce the size of leiomyoma. Twelve uterine leiomyomas were obtained from pre-menopausal women with regular menstrual cycles in the proliferative phase who underwent abdominal hysterectomy or myomectomy in Imam Reza Hospital. The patients had received no hormonal therapy for at least 6 months before surgery. The comparative effects of treatment with graded concentrations of raloxifene (in five groups with various concentrations of 1، 2، 4، 6 and 8 micrograms per milliliter، respectively) and GnRH-a (in five groups، with concentrations of 50، 100، 200، 300 and 400 micrograms per milliliter، respectively) and combination of these two on Vascular Endothelial Growth Factor (VEGF) and inhibition of leiomyoma cell proliferation were determined. in the three treatment groups with graded concentration of raloxifene and GnRH-a and combined therapy، VEGF content significantly decreased (P<0. 05). The VEGF decreasing levels in the combined therapy، raloxifene and GnRH-a groups were 79. 16%، 64. 74% and 55. 29%، respectively (p<0. 05). The inhibition of cell growth was significantly different between the two treatment groups (P<0. 05). The inhibition of cell growth in the combined therapy group was 70. 77% followed by raloxifene (60. 76%) and GnRH-a (15. 83%)، which indicated a significant difference (P<0. 05). Treatment with graded concentrations of Raloxifene، GnRH-a and combination of both Raloxifene and GnRH-a significantly decreased the VEGF content and proliferation of leiomyoma cells.

The present study examined the effects of fear and anxiety on obsessive-compulsive signs with the mediation of affects among students.

This research was a correlational study with structural equation modeling approach. 423 (192 males and 231 females) participants were selected using multistage sampling from among all students studying at Razi University in Kermanshah. They completed self-report measures of Behavioural Approach System/Behavioural Inhibition System Scale، Positive and Negative Affect Schedule-Expended Form and Dimensional Obsessive-Compulsive Scale. The raw data collected were analyzed by Structural Equation Modeling (SEM) with maximum likelihood estimation using LISREL software (Version 8. 80).

The results showed that the theoretical models are a good fit. The Behavioral Inhibition System (BIS) affected the obsessive-compulsive signs both directly and indirectly through negative affect. Besides، fear and guilt mediated the effect of fight-flight-freeze system and behavioral inhibition system on obsessive-compulsive signs، respectively،.

Affects play an important role in determining the effects of the brain behavioral system of fear (fight-fight-freeze) on Obsessive-Compulsive (OC) signs.

Hepatitis B is a common viral disease and one of the most common causes of cirrhosis and Hepatocellular Carcinoma (HCC). This disease is preventable via vaccination in most individuals. The aim of this study was to compare the accelerated and classic vaccination schedules against hepatitis B in the short-term production of protective antibody level.

A couple of scientific internet resources were searched to find the relevant studies. The abstracts of 156 studies and full texts of some of them were reviewed and finally، 19 articles relevant to the objective of the study were selected. From among the 19 articles remained، 11 articles with a score of 3 out of 5 (JADAD SCORE) were included as high quality studies.

The antibody level of 10 mIU/ml or above was considered as positive vaccination response. According to the results of random effect model، no statistically significant difference was reported between the accelerated and conventional vaccination methods in terms of serum protection (OR=0653، CI: 0. 425-1. 004). However، it seems that the accelerated method is less strong.

Although it seems accelerated vaccination method has less power، the difference has been trivial in most of the studies. Accelerated vaccination is recommended in situations where faster protective antibody level is needed.

Eating disorder is a common problem in teenage girls and young women. In clinical situations، brief screening is necessary to recognize the patients. The present research aimed to evaluate the psychometric properties of Eating Disorder Diagnostic Scale (EDDS). The study sample included 431 females selected from among the females referring to Shiraz’s sport clubs using convenience sampling. The participants in this research responded to the EDDS that was translated by the researcher and their BMI index was calculated. The internal consistency coefficients، and Spearman-Brown and Guttmann spilt-half correlations were 0. 84، 0. 82 and 0. 83، respectively. The findings showed that the agreement rate of the instrument with the clinician’s diagnosis and confirmatory factor analysis، and the correlation between each question and the whole score were appropriate. In general، the results of this research showed that the Persian version of Eating Disorder Diagnostic Scale (EDDS) has appropriate validity and reliability and can be used in clinical and research situations for the assessment of eating disorder.

Determining hepatitis C genotypes is important to detect the various aspects of this infection، including its epidemiology، pathogenesis and response to anti-viral treatments. The aim of this study was to investigate the prevalence of hepatitis C genotypes in patients admitted to the Infectious Diseases Clinic in Khorramabad. Out of all the patients admitted to the Infectious Disease Clinic in Khorramabad in a four-year period (April 2009 to March 2013)، 120 patients who met the inclusion criteria of the study were evaluated. The PCR method was used to examine the serums of the patients with hepatitis C in terms of the type of genotype. Out of 120 patients، 101 (84. 2%) were male and 19 (15. 8%) were female. The most prevalent genotypes were 3a (65%)، 1a (24. 2%)، 1a/1b (5%)، and 2 (1. 7%)، respectively. The genotypes of 5 patients (4. 2%) could not be determined. No significant relationships were found between gender and genotype، and age group and genotype. Moreover، 18. 3% of the patients were HIV-positive. In this study، genotype 3a، the most prevalent genotype، was not consistent with the prevalent genotypes in Arab، European، American، and African countries. Furthermore، genotype 1a was the second most prevalent genotype، while it has been reported as the most prevalent genotype by numerous studies conducted in Iran.

Brucellosis is a zoonotic، chronic and infectious disease in many developing countries، including Iran. This study investigated some of the epidemiological features of the disease in Kermanshah province in 2011.

In this descriptive study، all of the patients with brucellosis reported to the health center of the province during the year 2011 were studied. The demographic and some epidemiologic parameters of the disease were recorded in the questionnaires. All collected data were analyzed using SPSS (version19) software.

Totally، 777 cases of brucellosis were reported to the health center of the province in 2011. The lowest incidence of brucellosis in the province was 40. 8/100000. The highest and lowest incidence rates were seen in Dalahoo (215. 2/100 000) and Javanrood (12. 6/100 000) districts، respectively. 47. 4% of the patients were female and about half of the patients were under 30 years old. Raw milk was the most common cause of the disease consumed by 81. 9% of the cases. Also، 87. 6% of the patients were living in rural areas and the peak of disease was seen in the spring and summer months.

Despite the significant reduction، it seems that the incidence of disease in some rural areas of the districts such as Dalahoo and Sarpol-e-Zahab are very high.

Brucellosis is a zoonotic disease that mandates a high cost on nations. The aim of this study was to compare the human brucellosis incidence rates in Eslam Abad-e-Gharb، Kermanshah province and Iran from 2006 to 2010. In this cross-sectional study، the incidence rates of human brucellosis in EslamAbad-e-Gharb town، Kermanshah province and Iranwere obtained from the existing files and compared by Z test. There were 458 cases of human brucellosis in Eslam Abad-e-Gharb. The incidence rate of this disease (per 100،000) in Eslam Abad-e-Gharb (42-76. 4) was higher than those of Kermanshah province (37. 4-56. 3) and Iran (15. 9-34) during the five-year period (P=0. 01). the human brucellosis incidence rate had a descending trend in the three regions investigated. Although the incidence rate of this disease was declining، it was more than twice the national incidence rate in EslamAbad-e-Gharb. This issue needs the immediate attention of health decision-makers in Kermanshah province.