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فهرست مطالب نویسنده:

javad masoumi

  • Mohsen Abbaszadeh, Bahar Naseri, Mohammad Taghizadeh-Teymorloei, Amirhossein Mardi, Mohammad Reza Javan, Javad Masoumi, Farid Ghorbaninezhad, Amirhossein Hatami‐Sadr, Şengül Tural, Behzad Baradaran*, Mohammad Reza Sadeghi

    Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) in linking innate and adaptive immune responses. In addition to presenting antigens to T cells, DCs must also provide co-stimulatory signals along with cytokines for T cells to induce an appropriate cellular immune response. Tolerance is also established and maintained by DCs under homeostatic circumstances. There is remarkable phenotypic heterogeneity in DCs, each with different functional flexibility and specific expression of various markers. The three primary categories of DCs comprise conventional DCs (cDCs), plasmacytoid DCs (pDCs), and monocyte-derived DCs (moDCs). Langerhans cells (LCs) are another type of DCs, which are found in the skin's epidermal layer. DCs may be positioned or triggered inappropriately as a result of dysregulation of DC. This phenomenon can cause an imbalance in immune responses and even immune-related pathological disorders, i.e., autoimmune diseases and malignancies. Herein, by reviewing the ontogeny, biology, characteristics, and function of DCs subsets in immune system, we discuss the contribution of these cells in the mentioned immune-related disorders.

    Keywords: Conventional Dcs, Plasmacytoid Dcs, Monocyte-Derived Dcs, Langerhans Cells, Immune-Related Disorders
  • Mohsen Abbaszadeh, Bahar Naseri, Javad Masoumi, Elham Baghbani, Behzad Baradaran, Mohammad Reza Sadeghi *
    Introduction

    Dendritic cells (DCs) possess specialized abilities to present antigens and stimulate T cells, making them essential in triggering adaptive immune responses. Thalidomide and its derivatives are classified as a group of medications that possess immunomodulatory properties. Numerous studies have demonstrated the contentious impact of these drugs on DCs. Therefore, the objective of the present study was to assess the influence of Thalidomide therapy on the maturation and stimulation of monocyte-derived DCs, and subsequently examine the consequences of these treated DCs on the immune responses of autologous T cells.

    Methods

    The immature DCs derived from monocytes were subjected to exposure to Thalidomide and Lipopolysaccharides (LPS) on the fifth day of differentiation, followed by a 24-hour incubation period. On the sixth day, the phenotypic features of the DCs in both the control and treatment groups were assessed using flow cytometry. Subsequently, the gene expression in both the DCs and autologous T cells co-cultured with the DCs was evaluated using the real-time PCR method.

    Results

    Thalidomide-treated DCs exhibited a significant augmentation in the expression of maturation and stimulatory surface markers CD11c, HLA-DR, and CD86 (P ≤ 0.01), as well as gene expression of TNF-α and IL-12 (P ≤ 0.01) when compared to the control group. Furthermore, co-culture of Thalidomide-treated DCs with T cells increased T-bet and IFN-γ (P ≤ 0.01) expression, while diminished FOXP3 and TGF-β (P ≤ 0.01) expression compared to T cells co-cultured with untreated DCs.

    Conclusion

    Our findings indicate that in vitro Thalidomide treatment shifts DCs towards an immunogenic state and elevates their T helper 1 inducing capacity, which may be efficient in immunotherapy of various cancers.

    Keywords: Monocyte-Derived Dendritic Cell, T Cell, Thalidomide, Immunomodulation, Cancer
  • Sepideh Sohrabi, Shiva Alipour, Zahra Ghahramanipour, Javad Masoumi, Behzad Baradaran *
    Introduction

    Signal transducer and activator of transcriptions (STATs) factors as critical proteins in cell signaling regulate diverse biological processes such as differentiation and proliferation of cells. STATs have been shown to play distinct roles in modulating immune responses mediated by innate and adaptive immune cell subsets due to their significant roles in cytokine signaling.

    Methods

    In the current study, we review recent studies on the contribution of individual STAT proteins to cytokine signaling, development, and activity of diverse immune cells that constitute the whole immune system and help its performance against endogenous or exogenous agents with a particular focus on meaningful STAT factor in each of innate and adaptive immune cells’ subsets to clarify their function in favor of the tumor or against it.

    Results

    Dysregulation of signaling pathways in the immune cells is associated with various immune disorders, such as the inability of immune system cells in the effective destruction of cancerous cells. Increase of knowledge about these pathways’ functions is essential to understand how they can be effectively targeted to eliminate tumors.

    Conclusion

    The majority of immune cells use the Jak/STAT signaling pathway, which is one of the most important signaling pathways with a role in induction of proper immune responses. Since each of the STAT factors has a specific role in diverse immune cells’ subsets, appropriate targeting of them can be a promising strategy for patients who suffer from immune system disorders; specifically it can be beneficial as an approach for cancer immunotherapy.

    Keywords: Innate Immune System, Adaptive Immune System, STAT, Cancer
  • Soheila Yousefi, Pedram Basirjafar, Raziyeh Zandvakili, Javad Masoumi, Nahid Zainodini, Hossein Khorramdelazad, Mahsa Gheitasi, Abdollah Jafarzadeh *
    Background
    It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cell suppression together with Treg cell hyperactivation contribute to tumor development. Glycyrrhiza glabra (G. glabra) has various immunomodulatory and anti-tumorigenic properties.
    Objective
    To explore the impacts of G. glabra extract on different parameters related to TH1 and Treg cells using a breast cancer (BC) model.
    Methods
    Four groups of Balb/C mice bearing 4T1 cell-induced BC were treated intraperitoneally with either saline or G. glabra extract at dosages of 50, 100 and 150 mg/kg (G. glabra-50, G. glabra-100, and G. glabra-150, respectively). After sacrificing animals on day 26, the frequency of splenic TH1 and Treg cells, the levels of serum IFN-γ, TGF-β, and IL-12, and intra-tumoral expressions of granzyme-B, T-bet, and FOXP3 were assessed.
    Results
    Compared to untreated tumor control (UTC) group, treatment with G. glabra-50, G. glabra-100, or G. glabra-150 increased the survival rate, percentage of TH1 cells, and T-bet expression. Conversely, they reduced the percentage of Treg cells, and serum TGF-β levels. In comparison to the UTC group, treatment with G. glabra-50 and G. glabra-150 increased the serum IL-12 levels. Treatment with G. glabra-100 and G. glabra-150 boosted granzyme-B expression. Treatment with G. glabra-150 elevated IFN-γ levels, while treatment with G. glabra-50 decreased the FOXP3 expression. IL-12 levels were higher in mice treated with G. glabra-150 compared to those treated with G. glabra-100.
    Conclusion
    Treatment of mice with BC using G. glabra extract improved survival rate, reduced tumor growth, and modulated T cell-mediated immune responses.
    Keywords: Breast Cancer, Cytokines, Glycyrrhiza Glabra, Mice, Regulatory T Cells, TH1 Cells
  • جواد معصومی*
    اعتیاد و مصرف مواد مخدر پدیده ای است که آینده کشور را در ابعاد گوناگون با چالش مواجه می سازد. بدین منظور مطالعه و برنامه ریزی به منظور مقابله با این معضل اجتماعی، نیازمند شناخت و بررسی عوامل موثر بر رواج مصرف مواد مخدر می باشد. پژوهش حاضر باهدف شناخت و اولویت بندی عوامل موثر بر گرایش به اعتیاد و مصرف مواد مخدر در نواحی روستایی دهستان بناب استان زنجان انجام گردیده است. پژوهش حاضر از لحاظ هدف کاربردی و روش انجام آن توصیفی_تحلیلی و گردآوری داده ها بر اساس روش کتابخانه ای و میدانی می باشد. جامعه آماری پژوهش سرپرستان خانوار ساکن در روستا و افراد معتاد می باشد. به علت تعداد بالای روستاهای دهستان موردمطالعه که تعداد 25 روستای دارای سکنه بوده تعداد 10 روستا از طریق نمونه گیری خوشه ای انتخاب و بر مبنای تعداد جمعیت، تعداد نمونه هر طبقه جمعیتی مشخص شد. روش تحقیق با استفاده از مطالعات کتابخانه ای و تهیه و تکمیل پرسشنامه ای محرمانه بوده که روایی آن با استفاده از نظر متخصصان تائید شد. پایایی پرسشنامه با استفاده از ضریب آلفای کرونباخ (0/72) مورد تایید قرار گرفت. یافته های تحقیق نشان داد که بر اساس دیدگاه جامعه آماری مهم ترین عوامل موثر در پیشگیری از اعتیاد به مواد مخدر نظارت خانواده ها، ایجاد و تنوع فرصت های شغلی و همچنین توسعه امکانات گذران اوقات فراغت می باشد. مجموعه ای از عوامل در بروز و گسترش مصرف مواد مخدر در روستاها نقش دارند که از جمله آن ها می توان به عوامل فردی، نظام تربیتی خانواده، اقتصادی، اجتماعی و در نهایت عامل فرهنگی اشاره نمود.
    کلید واژگان: اعتیاد، مصرف مواد مخدر، نواحی روستایی
    Javad Masoumi *
    Addiction and drug use is a phenomenon that challenges the future of the country in various dimensions. For this purpose, studying and planning in order to deal with this social problem requires knowing and investigating the factors affecting the prevalence of drug use. The present research was conducted to recognize and prioritize the factors affecting addiction and drug use in the rural areas of Bonab villages, Zanjan province. The current study is applied in terms of purpose and the method of doing it is descriptive-analytical and data collection based on library and field methods.The statistical population of the research is the heads of households living in the village and addicted people. Due to the high number of villages in the studied village, which was 25 inhabited villages, 10 villages were selected through cluster sampling, and based on the number of population, the number of samples for each population class was determined. The reliability of the questionnaire was confirmed using Cronbach's alpha coefficient (0.72). The findings of the research showed that based on the perspective of the statistical population, the most important effective factors in preventing drug addiction are the supervision of families, creating and diversifying job opportunities, and also the development of leisure facilities. A setof factors play a role in the occurrence and spread of drug use in villages, including individual factors, family education system, economic- Social, and finally cultural factor mentioned
    Keywords: Addiction, Drug Use, Rural Areas
  • جواد معصومی*

    تبیین موضوع سلامت جسم و روح بر اساس متون اسلامی امری ضروری می باشد. این مطالعه دستیابی به سلامت جسم و روح خانوارهای ساکن در روستا را بر اساس عمل به آموزه های طبی امام رضا علیه السلام در بازه زمانی شش ماهه آخر سال 1401 و شش ماهه اول سال 1402 و با تقسیم روستاییان به دو گروه کنترل و آزمون مورد بررسی قرار داده است. روش تحقیق از نظر هدف کاربردی و از لحاظ روش تحقیق پیمایشی و استفاده از آزمون های آماری است که بخش عمده ای از آن بر اساس داده های میدانی و تکمیل پرسشنامه از جامعه آماری در بازه زمانی مذکور در روستاهای بالای 1000نفر جمعیت استان زنجان می باشد که با فرمول نمونه گیری کوکران از  375سرپرست خانوار نمونه منطقه جمع آوری شده است و با استفاده از شاخص های سلامت جسم و روان بدست آمده طبق نظر متخصصان و استفاده از آزمون های آماری تحلیل واریانس، آزمون مقایسه  Tنمونه های زوجی و ضریب همبستگی پیرسون تجزیه و تحلیل شده است. میانگین سطح سلامت روستاییان با عمل به آموزه های طبی امام رضا علیه السلام در شش ماهه آخر سال 1401 و بعد از بررسی مجدد در شش ماهه اول 1402 در دو گروه کنترل و آزمون نشانگر آن است که بین عمل به آموزه های طبی و سلامت جسم و روح همبستگی معنی دار و مثبتی وجود دارد. تاثیر بالای آموزه های طبی امام رضا علیه السلام در سلامت جسمی و روحی خانوارهای روستایی آشکار می باشد. استفاده از مطالعات پیمایشی و روش تحقیق کمی در تاثیر استفاده عملی از آموزه های طبی امام رضا علیه السلام برای نخستین بار انجام شده است.

    کلید واژگان: امام رضا علیه السلام، آموزه های طبی، سلامت جسم و روح، خانوارهای روستایی، شاخص های سلامت
    Javad Masoumi *

    It is necessary to explain the health of body and soul based on Islamic texts. This study examines the physical and mental health of the families living in the village based on the medical teachings of Imam Reza, peace be upon him, in the period of the last six months of 1401 and the first six months of 1402, and by dividing the villagers into two control and experimental groups. have given. The research method is applied in terms of the purpose and in terms of the survey research method and the use of statistical tests, a major part of which is based on field data and completing a questionnaire from the statistical population in the mentioned time period in the villages with a population of more than 1000 people in Zanjan province, which is based on the Kochran sampling formula. A sample of 375 heads of households in the region has been collected and analyzed using physical and mental health indicators obtained according to the experts' opinion and statistical tests of analysis of variance, T-test of paired samples and Pearson's correlation coefficient. The average level of health of the villagers by following the medical teachings of Imam Reza (a.s.) in the last six months of 1401 and after re-examination in the first six months of 1402 in two control and test groups shows that there is a correlation between following the medical teachings and the health of the body and soul. There is a meaningful and positive. The high impact of Imam Reza's medical teachings on the physical and mental health of rural households is obvious. The use of survey studies and quantitative research methods on the effect of the practical use of the medical teachings of Imam Reza (peace be upon him) has been done for the first time.

    Keywords: Imam Reza, Peace Be Upon Him, Medical Teachings, Physical, Mental Health, Rural Households, Health Indicators
  • جواد معصومی، سعید پاکدلان، حمید توکلی، فائزه باقری دادوکلائی

    هدف اصلی این پژوهش بررسی دامنه یا وسعت مالکیت بر بازده اضافی سهام (صرف ریسک سهام) می باشد. با استفاده از داده های معاملاتی ماهانه ی شرکت های پذیرفته شده در بورس اواق بهادار تهران، وسعت مالکیت مبتنی بر معاملات با استفاده از حجم خریدار و حجم فروشنده در سهام جداگانه ایجاد شد و نقش وسعت مالکیت در بازده اضافی سهام (صرف ریسک سهام) بررسی شد. در راستای بررسی این موضوع، فرضیه های پژوهش بر مبنای یک نمونه آماری متشکل از 92 شرکت طی سال های 1394 لغایت 1398 و با استفاده از الگوهای رگرسیونی چندمتغیره مبتنی بر داده های ترکیبی مورد آزمون قرار گرفت. نتایج پژوهش نشان میدهد که بین وسعت مالکیت و بازده اضافی سهام رابطه مثبت و معنی داری وجود دارد. همچنین نتایج نشان داد که بین متغیرهای کنترلی سه عامل فاما و فرنچ شامل صرف ریسک، عامل اندازه، عامل ارزش و متغیرهای کنترلی سطح شرکت یعنی عمر، نسبت ارزش دفتری به بازار و نرخ گردش سهام با بازده اضافی سهام رابطه ی مثبت و معنی دار و بین متغیر کنترلی اندازه شرکت با بازده اضافی سهام رابطه منفی و معنی داری وجود دارد. بر اساس نتایج پژوهش به مدیران و سرمایه گذاران پیشنهاد می شود که در تصمیم گیری های کلیدی سرمایه گذاری شرکت ها، باید از رابطه بین وسعت مالکیت و بازده اضافی سهام آگاهی داشته باشند تا از بروز زیان های ناخواسته که ممکن است ناشی از تصمیم های غیرمنطقی باشد جلوگیری شود.

    کلید واژگان: وسعت مالکیت، حجم معاملات سهام، بازده مازاد سهام، صرف ریسک سهام
    Javad Masoumi, Saeed Pakdlan, Hamid Tavakoli, Faezeh Bagheri Dadoklai

    The main purpose of this study is to investigate the scope or breadth of ownership on stock excess returns (Stock risk premium). Using Monthly trading data from the Tehran Stock Market, we construct a trading - ased breadth of ownership measure using buyer-initiated volume and seller-initiated volume in individual stocks, and further examine the role of breadth of ownership in stock excess returns (Stock risk premium). In order to investigate this issue, research hypotheses based on a statistical sample consisting of 92 companies during the years 2015 to 2019 and tested using multivariate regression models based on composite data. The results show that there is a positive and significant relationship between the breadth of ownership and stock excess returns. The results also showed that there was a positive and significant relationship between the control variables of three factors, Fama and French, including risk premium, size factor, value factor, and control variables of company level, ie life, book value to market ratio and stock turnover rate with stock excess returns, and there is a negative and significant relationship between the control variable of company size and stock excess returns. Based on the research results, it is suggested to managers and investors that in key investment decisions of companies, they should have a relationship between the Breadth of ownership (stock trading volume) and stock excess returns to avoid unintended losses that may result from irrational decisions.

    Keywords: Breadth of ownership, Stock trading volume, Stock excess returns, Stock risk premium
  • Fereshteh Taghipour, Omolbanin Oladpour, Mohammad Taghi Rezayati, Hossain Khorramdelazad, Maryam Nemati, Zahra Taghipour, Javad Masoumi, Zuhair Mohammad Hassan, Abdollah Jafarzadeh

    Metformin, cimetidine, and ibuprofen separately exhibit immunomodulatory and anti-tumorigenic effects. Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model. For establishing the BC model, four groups of Balb/c mice were challenged with the carcinoma cell line. After 11-30 days post-induction, they were treated intraperitoneally (with metformin (200 mg/kg), "metformin plus cimetidine (20 mg/kg)"; "metformin plus ibuprofen (20 mg/kg)", or with all three drugs in mentioned doses. Untreated BC and without tumor mice were enrolled as control groups. On day 31, splenic Th1 and Treg cell frequencies, serum interferon-gamma (IFN-γ), and transforming growth factor-beta (TGF-β) concentration, and intra-tumoral T-bet, TGF-β, and forkhead box protein P3 (FOXP3) expression were measured; using flow cytometry, enzyme-linked immunosorbent assay (ELISA), and real-time-PCR, respectively. Treatment of the BC mice with metformin alone and in combination with cimetidine and/or ibuprofen enhanced the frequency of Th1 cells, and IFN-γ concentration, while it resulted in a decrease in the frequency of Treg cells, serum TGF-β concentration, and the expression of FOXP3 and TGF-β compared with un-treated BC mice. FOXP3 expression in the metformin-treated group was lower in mice who received combination therapy. Survival rate and body weight were increased, while tumor size and spleen index were reduced in mice treated with metformin alone and its combination with cimetidine and/or ibuprofen. No remarkable differences were found between metformin-treated mice and those who received combination therapies regarding Th1 and Treg cell percentages, TGF-β expression, body weight, tumor size, and spleen index. The benefits of combinational therapy may be largely attributed to metformin. Immunotherapeutic potentials of metformin in cancers need further considerations.

    Keywords: Breast neoplasms, Cimetidine, Ibuprofen, Metformin, Mice, Tlymphocytes
  • جواد معصومی، هاشم نیکومرام*، قدرت الله طالب نیا، فریدون رهنمای رودپشتی

    هدف پژوهش حاضر، شناسایی و رتبه بندی عوامل موثر بر کشف تقلب صورت های مالی با استفاده از تکنیک قضاوت به روش فرآیند سلسله مراتبی و تکنیک های داده کاوی می باشد. جامعه ی آماری شامل حسابرسان ارشد، سرپرستان، سرپرستان ارشد، مدیر حسابرسی و شریک موسسه ی و همچنین شرکت های بورس اوراق بهادار تهران می باشد. در راستای هدف پژوهش، تعداد 56 پرسش نامه و داده های 109 شرکت بورسی طی دوره ی زمانی 1391 تا 1396 گردآوری و مورد تحلیل قرار گرفت. بر اساس تکنیک قضاوت، بعد فشار اولویت اول، فرصت دومین عامل و توجیه به عنوان سومین عامل موثر بر کشف تقلب رتبه بندی می شوند که این نتایج با سایر تکینک-ها تفاوت دارد. از لحاظ تجربی، رویکردهای شبکه ی عصبی و درخت تصمیم در طبقه بندی صحیح نمونه ی مورد آموزش و آزمایش شبکه از نرخ دقت 65/98 درصد (شبکه ی عصبی)، 5/91 درصد (درخت تصمیم) و 79/69 درصد (شبکه ی عصبی)، 10/69 درصد (درخت تصمیم) برخوردار است، که از مدل لجستیک دقیق تر می باشد که در این روش تنها به 32/72 درصد و 10/88 درصد طبقه بندی صحیح در ارزیابی وقوع تقلب می رسد. علاوه بر این، به طور قابل توجه خطای نوع دوم ناشی از مدل درخت تصمیم در مقایسه با بکارگیری شبکه ی عصبی و مدل لجستیک از 18/58 درصد و 7/72 درصد به 6/55 درصد کاهش می یابد. با توجه به شاخص دقت، مدل درخت تصمیم نسبت به سایر مدل ها از کارآیی بیشتری برخوردار است؛ بنابراین از بین تکنیک های داده کاوی، وزن هر کدام از متغیرهای ورودی مدل درخت تصمیم مبنای رتبه بندی نهایی متغیرهای پژوهش قرار گرفته است.

    کلید واژگان: تقلب در صورت های مالی، قضاوت حسابرس، شبکه های عصبی مصنوعی، درخت تصمیم، روش فرآیند سلسله مراتبی
    Javad Masoumi, Hashem Nikoomaram *, GhodratAllah Talebnia, Fraydoon Rahnamay Roodposhti

    The objective of this study is to identify and ranking of factors affecting detecting the financial statement frauds using the judgment technique based on the Analytic Hierarchy Process and data mining techniques techniques. The population of the study comprised of senior auditors, supervisors, senior supervisors, audit manager and partner of the audit institute employed in audit institutes member and also companies listed in the Tehran Stock Exchange. In order to the research goal, 56 questionnaires and 109 Listed for the year 2012-2017 and analyzed. Based on the technique of judgment, the pressure dimension of the first priority, opportunity, second factor and rationalization are ranked as the third effective factor on the detection of fraud. These results are different with other techniques. Empirically, the ANNs and CART approaches work with the training and testing samples in a correct classification rate of 98/65% (ANNs) & 91.5% (CART) and 69/79% (ANNs) & 69.10% (CART), respectively, which is more accurate than the logistic model that only reaches 72.32% and 88.10% of the correct classification in assessing the fraud presence. In addition, type II error of CART drops significantly to 58.18% from 72.7% and 55.6% compared to the ones using ANNs and logistic models. According to the accuracy index, the decision tree model is more efficient than other models; therefore, among the data mining techniques, the weight of each of the input variables of the decision tree is the basis for the final ranking of the research variables

    Keywords: Fraud in Financial Statements, Auditor Judgment, Artificial Neural Networks, Decision Trees, Analytic Hierarchy Process Method
  • Saeideh Sobati, Amir Shakouri, Mahdi Edalati, Daryoush Mohammadnejad, Reza Parvan, Javad Masoumi, Jalal Abdolalizadeh *

    Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a vital modulator of low-densitylipoprotein cholesterol (LDL-C) , is raised in hepatocytes and released into plasma where it bindsto LDL receptors (LDLR), leading to their cleavage. PCSK9 adheres to the epidermal growthfactor-like repeat A (EGF-A) domain of the LDLR which is confirmed by crystallography. LDLRexpression is adjusted at the transcriptional level through sterol regulatory element bindingprotein 2 (SREBP-2) and at the post translational stages, specifically through PCSK9, and theinducible degrader of the LDLR PCSK9 inhibition is an appealing new method for reducing theconcentration of LDL-C. In this review the role of PCSK9 in lipid homeostasis was elucidated, theeffect of PCSK9 on atherosclerosis was highlighted, and contemporary therapeutic techniquesthat focused on PCSK9 were summarized. Several restoration methods to inhibit PCSK9 havebeen proposed which concentrate on both extracellular and intracellular PCSK9, and theyinclude blockage of PCSK9 production by using gene silencing agents and blockage of it’sbinding to LDLR through antibodies and inhibition of PCSK9 autocatalytic processes by tinymolecule inhibitors.

    Keywords: Atherosclerosis, Cholesterol, Coronary heart disease, LDL, Monoclonal antibody, PCSK9
  • Alireza Vakilian, Javad Masoumi, Saeid Mirzaee, Hossein Khorramdelazad*
    Background
    Recent evidence has indicated that beta-secretase 1 (BACE1) is involved in the production of amyloid beta (Aβ) in patients affected with Alzheimer’s disease (AD). Therefore; the purpose of this study was to measure mRNA and plasma levels of BACE1 in AD patients, as an early diagnosis biomarker for such individuals.
    Methods
    A total number of thirty AD patients and thirty normal subjects as controls were recriuted in the present study. Plasma levels of BACE1 were then examined via enzyme-linked immunosorbent assay (ELISA) and also mRNA expression of BACE1 in total blood was measured using real-time PCR technique.
    Results
    The findings revealed a significant difference in gene expression of BACE1 in the peripheral blood of AD patients compared with that in controls (p<0.0001). Additionally, elevated plasma levels of BACE1 were found in AD patients compared with those in normal subjects (p<0.01). Statistical analyses also demonstrated no correlation between expression (mRNA and protein) of BACE1 in both AD patients and controls and age or the results of Mini-Mental State Examination (MMSE) scale (p>0.05).
    Conclusion
    Given the importance of early diagnosis of AD patients, it was suggested that the measurement of plasma levels and also mRNA expression of BACE1 might be a valuable blood-based biomarker used in preference to other invasive diagnostic methods such as cerebrospinal fluid (CSF) analysis.
    Keywords: BACE1, Alzheimer’s disease, biomarker
  • جواد معصومی*، حمیده حمیدیان
    در این مقاله به بررسی اثر اعلان تعدیل سود پیش بینی شده بر قیمت سهام شرکت های پذیرفته شده در بورس اوراق بهادار تهران می پردازیم. به این منظور از روش شناسی استاندارد مطالعات رویدادی استفاده شده است. محدوده رویداد شامل 11 روز (5 روز قبل تا 5 روز پس از اعلان تعدیل) و محدوده برآورد 180 روز قبل از شروع محدوده رویداد در نظر گرفته شده است. نمونه مورد بررسی شامل 2532 مورد تعدیل سود پیش بینی شده طی سال های 1386 الی 1390 می باشد که توسط شرکت های پذیرفته شده در بورس اوراق بهادار تهران اعلان شده است. بازده غیرعادی طبق روش بازده تعدیل شده بازار محاسبه شده است. نتایج نشان می دهد اعلان تعدیل مثبت سود پیش بینی شده با افزایش قیمت سهام و اعلان تعدیل منفی سود پیش بینی شده با کاهش قیمت سهام همراه است.
    کلید واژگان: پژوهش رویدادی، تعدیل سود پیش بینی شده، بازده غیرعادی
    Javad Masoumi, Hamideh Hamidian
    This article examines common stock price behavior which accompanied the mandated disclosure of 2,532 forecasted earnings adjustment during the years 1386-1390 (Iranian calendar). We use event study methodology applying 11 days as event window (5 days before and 5 days after announcement) and 180 days as estimation period. Abnormal return calculated by four methods include mean adjusted return, market mean return, residual of market model and difference of CAPM. We found positive adjustments of forecasted earnings per share cause rise of stock price, but reduction of stock price because of negative adjustments of forecasted earnings per share is rejected.
    Keywords: Event Study, Adjustment of Forecasted Earnings Per Share, Abnormal Return
  • محمدحسین قائمی، قاسم عسگرزاده، جواد معصومی
    در این مقاله به بررسی کاربرد متغیرهای حسابداری در سنجش بازده غیرعادی در پژوهش های رویدادی پرداخته شده است. برای محاسبه بازده مورد انتظار از سه دسته معیار شامل معیارهای مبتنی بر متغیرهای حسابداری، متغیرهای بازار و اندازه شرکت استفاده شده است. برای ارزیابی سودمندی این معیارها در سنجش بازده غیرعادی و مقایسه توان آنها با یکدیگر، سه آماره آزمون شامل آماره پاتل، آماره بومر و همکاران و آماره مقطعی بکار گرفته شده است. نمونه مورد بررسی تحقیق شامل 183 شرکت است که برای محاسبه متغیرهای حسابداری، بازه زمانی 1389-1385 و برای تشکیل250 پرتفوی50 تایی جهت محاسبه بازده غیرعادی، بازه زمانی 01/05/1386 تا 31/04/1390 انتخاب شده است. نتایج شبیه سازی بیانگر این است که توان آماره های مبتنی بر متغیرهای حسابداری برای سنجش بازده غیرعادی، برابر میزان توان آماره های مبتنی بر متغیرهای بازار می باشد. به صورت مقایسه ای بین دو روش بازده تجمیعی و بازده یکسان، توان آماره های مختلف برای کشف بازده های غیرعادی در روش بازده تجمیعی نسبت به روش یکسان، بیشتر بوده است.
    کلید واژگان: پژوهش رویدادی، متغیرهای حسابداری، بازده تجمیعی، بازده یکسان
    Mohammad Hussein Ghaemi, Ghasem Asgarzadeh, Javad Masoumi
    This paper investigates the application of accounting variables in measuring abnormal return of stock in event studies. In order to calculate the expected return three type of measures are employed including measures based on accounting variables، market variables and firm size. For evaluation of usefulness of these measures in measuring abnormal return and comparing them together، three test statistics are applied including test statistic of Patell، Boehmer et al. and cross-sectional. The research sample is consisted of 183 firms in which the time period of (Iranian calendar) 1385:1389 is selected to measure the variables. Also، the abnormal return is calculated by selecting 250 portfolios including 50 elements. The results of simulation denotes that the power of statistics based on accounting variables in measuring abnormal return is similar to market variables. The power of all statistics for rejecting the zero hypotheses in lumped return procedure is greater than uniform procedure.
    Keywords: Event study, Accounting Variable, Test Statistic, Simulation
  • Mohammad Hussein Ghaemi, Reza Kamyab Teymouri, Javad Masoumi

    This study focused on measuring the alignment between AIS requirements and AIS capacity, then investigating whether this AIS alignment is linked to firm performance. AIS alignment with 19 accounting information characteristics for both requirement and capacity, with using questionnaire, was evaluated by financial managers of 93 manufacturing companies listed at Tehran stock exchange. Average of the return on equity, price/ earnings ratio, the carefulness of profit prediction and financial reports rapidness, for years of 1387 and 1388 (Iranian calendar) are used as performance criteria. Two statistical methods were performed to indicate association between AIS alignment and firms’ performance. The results of testing four hypotheses by two methods indicated that the companies with high AIS alignment had achieved better organizational performance than low AIS alignment. The findings provided evidence of the positive relation between AIS alignment and firms’ performance. Since performance and efficiency are important for the companies, investors, bankers and country industrial development planning, therefore training accountants can help successful implementation of AIS.

    Keywords: AIS requirements, AIS capacity, AIS alignment, Firm performanc
  • محمدحسین قائمی، جواد معصومی
    در این مقاله با در نظر گرفتن رویداد تعدیل سود پیش بینی شده توسط شرکتهای پذیرفته شده در بورس اوراق بهادار تهران در سالهای 1386 تا 1388 با استفاده از سه روش طول محدوده زمانی اثرگذاری این رویداد بر بازار تعیین شده است؛ هم چنین رابطه بین طول این محدوده زمانی و مقدار سود غیرمنتظره مورد سنجش قرار گرفته است. نتایج نشاندهنده نبودن رابطه معنی دار بین این دو متغیر است.
    کلید واژگان: پژوهشهای رویدادی، محدوده زمانی رویداد، بازده غیرعادی، بورس اوراق بهادار تهران
    Mohammad Hossein Ghaemi, Javad Masoumi
    Event studies have found several applications in financial and accounting researches as the standard method to assess the average effect of some types of announcement on stock prices. In a large sample of announcements, event window length can be standardized (fixed) across observations, because the errors from having too long or too short event window should have small impact in average by the Law of Large Numbers. But in small samples (in emerging markets) we cannot use this procedure. Here, we examine various potential rules for determining the length of an event window when looking at limited number of observations. We consider the announcements of adjustment of predicted earnings (by companies) in Tehran Stock Exchange during 1386 to 1388. To determining the length of time period affecting the market, tree methods are used. We also examine the relationship between the length of event window and the amount of unexpected earnings.
سامانه نویسندگان
  • دکتر جواد معصومی
    دکتر جواد معصومی
    استادیار گروه حسابداری، واحد سبزوار، دانشگاه آزاد اسلامی، سبزوار، واحد سبزوار، دانشگاه آزاد اسلامی، سبزوار، ایران
  • مهندس جواد معصومی
    مهندس جواد معصومی
    (1389) کارشناسی ارشد جغرافیا و برنامه ریزی، دانشگاه زنجان
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