mohammad javad yazdan panah

Dyslipidemia has been reportedly associated with an increased risk of atherosclerosis among psoriatic patients. Dietary intake can be a key factor in the pathophysiology of psoriasis. Herein, we assessed serum lipid profile and dietary intake in psoriatic patients, in comparison with healthy subjects.

In this case-control study, 45 psoriatic patients and 43 healthy controls were evaluated. We estimated the macro/micronutrient intakes and energy, using a food frequency questionnaire (FFQ). Anthropometric parameters and serum levels of triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very low-density lipoproteins were assessed. The case group was categorized by severity measured by PASI score (mild<10, moderate 10-20, severe >20). Diet plan 6.0 was used to analyze FFQs and data were analyzed in SPSS 16.0, with p<0.05 considered significant.

The case group had markedly higher body mass index (BMI), LDL, and cholesterol and significantly lower HDL compared with controls (p<0.05). Carbohydrate, energy, fat intakes were significantly higher in cases, while folate, fiber, and vitamin E intakes were significantly lower in the case group, compared with the control group (p<0.05). BMI, cholesterol, and triglyceride values and dietary intakes of fiber and vitamin E were significantly associated with severity of psoriasis (p<0.05).

Serum lipid profile and dietary intake are substantially important in psoriasis severity. Therefore, close monitoring of lipid profile and BMI during admission and follow-up and dietary modification can improve the severity of psoriasis.

The aim of this study was to stereological evaluate of the protective effect of pancreatin on morphological changes in mice kidney after treatment with L-arginine .

To conduct research, 50 adult male rats weighing 30±2 gr were divided into 5 groups (equal). In the control group, no administration was made. The pancreatitis induction groups received 2 doses of 300 and 400 mg/100 g body weight of L-arginine. To the induction groups with two different doses, therapeutic drug was prescribed 3.5 pp. of lipase-pancreatin. All treatments were received for 3 consecutive days once a day from L-arginine solution and 72 hours later, a lipase-pancreatin solution was administered to groups of pancreatitis for 20 days .

The results showed that due to experimental pancreatitis, except for medulla volume, decreasing volume of renal cortex, proximal and distal convoluted tubules, and glomeruli was observed in the treated groups compared to the control group. By the administration of pancreatin lipase along with L-arginine, mean volume values of factors such as mean volume of renal cortex, proximal convoluted tubules and glomeruli, have gotten closed to the control group .

According to a final review of the findings, lipasepancreatin solution may be partially effective in mitigating the effects of pancreatitis induced by high doses of L-arginine

Human interleukin-24 (IL-24) is a cytokine belonging to the interleukin-10 (IL-10) family of cytokines, also known as melanoma differentiation-associated gene 7, due to its discovery as a tumor-suppressing protein. A tumor-suppressing protein, IL-24 is produced by a variety of cells, including cancerous and non-cancerous healthy cells. The aim of the present study was to evaluate serum IL-24 concentrations in different cancers and compare them with non-cancerous inflammations.

In this case-control study, we divided a total of 200 subjects into five groups of 40 control subjects without cancer and without Helicobacter Pylori (H. Pylori) infection, patients with gastric cancer and H. Pylori infection, patients with H. Pylori infection without cancer, and patients with breast cancer and without H. Pylori infection. We measured the serum IL-24 level using specific enzyme-linked immunosorbent assay (ELISA) kit; we analysed the data with SPSS software.

The level of IL-24 was significantly higher in breast cancer group (160.65±55pg/mL) (mean± SD) followed by gastric cancer with (76.2±16.27 pg/mL) (mean±SD) and without (72.5±17.84 pg/mL) (mean± SD) H. Pylori infection groups. The level of IL-24 in H. Pylori infected patients and controls were (32.78±12.96 pg/mL) (mean±SD) and (27.4±8.5 pg/mL (mean±SD)), respectively.

The mechanisms by which IL-24 is produced may be different between immune and cancer cells and serum IL-24 is more likely generated by immune cells than tumor cells. In breast cancer patients, estrogen or other sex hormones may provoke IL-24 production.

 Acanthosis nigricans (AN) is a condition with an important characteristics of symmetrical areas  of thickened skin with grayish brown Hyperpigmentation. The mucosa may show a papillomatous surface, with or without hyperpigmentation. Lips and sites at risk of trauma may be affected and palmoplantar might also be present. In some rare cases, acanthosis nigricans presents as a sign of internal neoplasia, mostly a gastrointestinal cancer, and is called malignant acanthosis nigricans (MAN).

In this study, a 55-year-old female Iranian patient with malignant acanthosis nigricans (MAN) is reported. She was seeking esthetic treatment for her oral and perioral regions. The peculiarity of this case is simultaneous skin manifestation consistent with MAN, “tripe palms,”(TP) , and Leser-Trélat (LT) sign and mucosal changes in the oral cavity such as papillomatosis and roughened surfaces of the lips, hard palate and buccal mucosa. These changes harbored gastric adenocarcinoma stage T3 N3, but the patient was asymptomatic except for pruritis.

There is an urgent need to suspect a correlation between oral and skin changes and the possibility of an internal neoplasia, therefore it is of utmost importance to refer these patients for early diagnosis of the underlying disease. This would improve the prognosis and lessen the consequences to a great extent.

L-arginine-induced experimental pancreatitis was evaluated as a distinct and new form of experimental pancreatitis with particular consideration to the therapeutic role of lipase-pancreatin and its effects on testicular tissue structure.

Fifty mice were classified into: 1) control; 2) induced pancreatitis (IP) by administration of L-arginine solution (300 mg/100g); 3) IP by L-arginine solution (300 mg/100g) along with lipase- pancreatin; 4) IP group with L-arginine solution (400 mg/100g); 5) IP group by L-arginine solution (400 mg/100g) along with lipase- pancreatin. L-arginine solution was administered only once at the beginning of the course by intraperitoneal injection and lipase-pancreatin treatments were twice daily for 14 consecutive days and started 72 hours later after L-arginine administration. Finally, tissues samples were prepared for stereological analysis by SPSS 23 software and one-way analysis of variance (One-way ANOVA).

The results showed that after experimental pancreatitis with different doses of L-arginine, the mean area and diameter of seminiferous tubules and the area of spermatogonia cells in the treated groups were significantly decreased or increased in comparison with the control group, However, no significant difference was observed in the area of spermatid cells and primary spermatocytes between the treatment and control groups. It was also observed that in the lipase-pancreatin-treated groups, the tissue changes caused by L-arginine-induced pancreatitis were significantly compensated.

It can be concluded that the L-arginine-induced pancreatitis has caused testicular tissue changes and the use of lipase-pancreatin solution has been shown to be partly effective in reducing these changes.

Acne is a common complain among post rhinoplasty patients. While rhinoplasty is done for aesthetic reasons and acne expressively affects the individual’s appearance, we aimed to study its incidence and role players.

A descriptive cross-sectional study was performed on 152 (143 females and 9 males) patients admitted for rhinoplasty during January 2016 to March 2017. Patients were examined by a dermatologist prior to surgery and 7, 30 and 90 days after rhinoplasty using the Global Acne Grading System and responded to a list of questions on the probable risk factors of acne. Psychological status was examined by the perceived stress scale-14 and the Hospital Anxiety and Depression Scale.

The patients' mean age was 28.9±3.82 yrs. Mild and moderate acne were observed in 21.7% (n=33) of the cases in the preoperative visit. The incidence of mild and moderate acne was 36.1%, 42.8% and 23% after 7, 30 and 90 days of surgery, respectively. One week after rhinoplasty, acne manifested in 14.9% of cases with no history of acne. Mean age significantly differed between those with and without post-surgical acne at all post-surgical visits (P> 0.001 and P=0.001 and P=0.015, respectively). Hospital anxiety and depression and perceived stress levels were significantly higher in patients who presented with acne on the first post-surgical visit compared to those with no acne presentations (P=0.04 and P=0.02, respectively).

External psychological stress may be the main role player in post-rhinoplasty acne. Consultation or referral of patients to an experienced psychologist

The relationship between HPV infection and skin squamous cell carcinoma (SCC) development in immunocompetent individuals is unclear. Therefore, the purpose of this study was to assess the association between HPV infection and skin SCC.
HPV DNA prevalence was evaluated in the paraffin embedded specimens of 70 immunocompetent patients, of which 35 patients had skin SCC and 35 had normal skin. PCR technique and GP6/5 primers were utilized for HPV DNA detection.
Based on this study, 14.3% of the cases (5 of 35, 2 with low risk and 3 with high risk viruses) and 2.9% of the controls (1 of 35 with low risk virus) had papilloma viruses. However, there was no significant statistical relationship between the HPV DNA presence and the SCC development in skin.
The direct effect of HPV on skin cancerogenesis remains questionable.

In this study, we evaluated the efficacy of intralesional injection of nimodipine in treatment of some cases of cutaneous leishmaniasis failed by a course of intralesional meglumine antimoniate (Glucantime).

This semi-experimental clinical trial study was done at the leishmaniasis research center of Mashhad University of Medical Sciences, Mashhad, Iran, from 2017 to 2018. For the patients whom their treatment had failed after a complete course of intralesional injection of meglumine antimoniate, intralesional injection of nimodipine was administered once a week for 6 weeks.

Ten patients were assessed. The mean size of the lesions were 1.35 cm at the first day of treatment, and became subsequently 1.35, 1.35, 1.33, 1.33, and 1.32 cm at the end of 2nd</sup> to 6th</sup> weeks of the treatment. Moreover, one month after the end of the treatment, the mean size of the lesions was 1.32 cm. The induration change of lesions was less than 25% for eight patients, and 25-50 percent for two other patients, after the fourth week; these changes were not statistically significant.

 There was no significant difference in size and induration of the lesions one month after the treatment with nimodipine compared to the first session of treatment. The concentration of the drug, or the selection of specific patients, may affect the results. This should be considered in the future studies.

The human T cell lymphotropic virus type-1 ( HTLV-1) is associated  with  adult  T cell  leukemia/lymphoma (ATL) and other  disorders, including  a slowly progressive  demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic  paraparesis  ( HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad.

Dermatological  findings  of  37  patients  with  HAM/TSP  were  investigated  and  were  compared  with  those of a  HTLV-1 negative control  group. Cutaneous biopsy was performed as needed and the results were statistically analyzed.

Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in control group (64.9%) had at least one skin lesion or history of skin lesion before (p=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (p=0.000). Only Xerosis was significantly associated with HAM/TSP.  

Skin manifestations were quite frequent in the patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP.

Many of the physical phenomena, like friction, backlash, drag, and etc., which appear in mechanical systems are inherently nonlinear and have destructive effects on the control systems behavior. Generally, they are modeled by hard nonlinearities. In this paper, two different methods are proposed to cope with the effects of hard nonlinearities which exist in friction various models. Simple inverted pendulum on a cart (SIPC) is considered as a test bed system, too. In the first technique, a nonlinear optimal controller based on approximate solution of Hamilton-Jacobi-Bellman (HJB) partial differential equation (PDE) is designed for the system and finally an adaptive anti disturbance technique is proposed to eliminate the friction destructive effects. In the second one, three continuous functions are used to approximate hard nonlinearities when they are augmented to system model. These techniques are compared with each other using simulations and their effectiveness are shown.

Both human T-cell lymphotropic virus type 1 (HTLV-1) infection and Behcet’s disease (BD) are common to a similar geographic area. Furthermore, some clinical presentations of BD and HTLV-1 infection, such as ocular lesions and neurologic involvement, are the same. The aim of this study was to assess a possible association between BD and HTLV-1 infection.
In this case-control study, the HTLV-1 infection frequency in BD patients was compared with that for the general population. The case group consisted of 68 patients with a definite diagnosis of BD who referred to a research center at Mashhad University of Medical Sciences in Mashhad, Iran. The control group consisted of 210 healthy individuals selected from the general population of Mashhad. The presence of HTLV antibodies in the sera was assessed using enzyme-linked immunosorbent assay and the seroreactive samples were confirmed by polymerase chain reaction.
HTLV-1 infection was detected in 4.41% (3/68) and 1.43% (3/210) of cases and controls, respectively; however, the difference was not statistically significant (P value = 0.16).
The prevalence of HTLV1 infection in patients with BD was three-fold higher than in the general population, which suggests an association between these two conditions.

In this paper, a novel adaptive sliding mode control for rigid robot manipulators is proposed. In the proposed system, since there may exist explicit unknown parameters and perturbations, a Lyapunov based approach is presented to increase system robustness, even in presence of arbitrarily large (but not infinite) discontinuous perturbations. To control and track the robot, a continuous controller is designed with two phases of adaptation. The first phase is related to the robot parameters and the other one is accounted for perturbation estimating. We investigated the stability in the sense of Lyapunov with derive adaptive laws and uniform ultimate boundedness in the applied worst condition. The simulation results for two degrees of freedom rigid robot manipulator effectively demonstrate capability of the mentioned approach. Moreover, the results show that the domain of attraction is so vast and a global uniform ultimate boundedness could be expected.

Pyoderma gangrenosum (PG) (ulcerating neutrophilic dermatosis) is a rare disease that about of half of these patients have a systemic disorder, particularly Crohn's and ulcerative colitis. In addition, inflammatory lesions play key role in its pathogenesis. In early diagnosis of disease, we will further prevent of serious consequences of the disease. In this report, a case of PG after the vaginal surgery with history of ulcerative colitis was introduced.
A 37-years old woman was admitted in an University Hospital of Mashhad University of Medical Sciences, Iran, in 2016 two weeks after genital surgery. The chief complaints were fever, painful tenderness, ulcerative lesion and inflammatory papule on surgical site and thigh. She suffered of fever despite received oral and then wide spectrum intravenous antibiotic therapy. Blood cultures and wound culture were negative. In addition to two deferent intravenous antibiotics, topical wound debridement was performed. Despite this course of treatment which did not improve the lesion, biopsy was performed. Histopathology features of biopsy specimen indicated prominent neutrophils mixed inflammation and lymphocytic vasculitis indicated as pyoderma gangrenous. The patient's medical history included associated ulcerative colitis from 18 years ago and she was under irregular oral receiving of Asacol (mesalamine). Intravenous corticosteroid therapy was administered which led to response of skin of right thigh and surgical site inflammation. After 6-months follow-up, the patient is still in good condition.
Based on major variable clinical manifestations and no diagnostic serologic test of pyoderma gangrenosum, diagnosis of this disease is difficult. Increased awareness about PG and exclusion of other etiologies such as inflammatory and immunologic disease will aid in prompting of pyoderma gangrenosum diagnosis and proper management of the disease.

Knowledge of the frequency and distribution of dermatoses in the male genital area and the effect of circumcision on these two factors are helpful guides to a correct diagnosis. The aim of this study was to determine the prevalence of genital dermatoses in circumcised men.
This cross-sectional study was done on all circumcised men complaining about skin lesions in their genital area.
Overall, 355 men with skin lesions in their genital area were enrolled in this study. All of them were circumcised for religious reasons. The mean age of the patients was 31.4±11.5 years. Most skin lesions were seen in the age group 20-29 years (152 cases, 42%). Genital warts were the most common disease (60 cases, 16.9%) followed by dermatitis (38 cases, 10.7%), lichen planus (36 cases, 10.1%), and scabies (36 cases, 10.1%). The most common site for genital lesions was the penile shaft (155 cases, 43.7%). Genital warts were more common on the pubic area, penile shaft, and penoscrotal and peno-pubic junction. We did not observe any cases of balanitis in our study.
Genital warts were the most common disease among our cases. Inflammatory dermatoses such as psoriasis and balanitis were less common in our population compared with other studies.

The association of granuloma annulare and some neoplasms is controversial. However, there is an increase in the number of case reports and relevant studies supporting the concept of granuloma annulare being associated with certain types of hematologic neoplasms and solid tumors. Herein, we describe a 54-year-old woman with a 20-month history of generalized annular lesions that did not respond to conventional treatment and was followed by breast cancer. Only two cases of granuloma annulare and breast cancer have been reported so far in the literature. We believe that these cases emphasize on considering granuloma annulare as a possible paraneoplastic dermatoses.

Cutaneous Leishmaniasis is one of the endemic diseases in Khorasan. Human is the main host in the urban cutaneous Leishmaniasis, so we can limit it's incidence -specially for drug resistant types- by early diagnosis and suitable treatment with correct dosage. There are many ambiguities in diagnosis and treatment of this disease, so we decided to evaluate knowledge of general practitioners about leishmaniasis in Mashhad and Chenaran to provide a guide for educational purpose. This study, a descriptive -analytic one, was done on 62 general physicians through a questionnaire whose reliability and validity were confirmed and containing 15 questions in three subjects including etiology & epidemiology, clinical   findings & diagnosis, and treatment.  We gathered our data from health care centers. To describe and analyze the data, frequency tables & diagrams and chi-square, Mann-Whitney, Kruskal –wallis & T-student tests were used. Among 62 physicians, 28 were male (45. 2 percent). 54. 6 percent of subjects were 31 to 40 years old. 40. 3% and 3. 2% of these physicians had low level and high level of information about leishmaniasis respectively. Levels of information between males and females were not statistically different. Sex, sites and years of practice, and participation in continuous educational courses did not significantly influence knowledge of physicians. Individuals under 30 years old in comparison with subjects above 40 years old had more information about Leishmaniasis AS indicated by the results, educational courses regarding different aspects of Leishmaniasis, especially its treatment during medical education and other follow-up continiuos educational courses, sould be considered as an educational need. Keywords: cutaneous leishmaniasis, general practitioners of health centers, treatment

Cryotherapy is one of the most common and effective treatments of anogenital warts, and trichloroacetic acid is one of the methods commonly used. The aim of this study was to compare the effect of cryotherapy and trichloroacetic acid in the treatment of anogenital warts.
This randomized clinical trial was conducted on patients with anogenital warts. The patients were divided into two groups; one group was treated with liquid nitrogen and the other with 70% trichloroacetic acid. In both groups, the treatment was done every two weeks until complete disappearance of the lesions or for 6 sessions.
In this study, 68 patients with anogenital warts were studied. After the 6th session, the cure rate of in the patients treated with trichloroacetic acid (94.1%) was higher than the patients treated with cryotherapy (85.3%) (P>0.05).
It seems that cryotherapy and trichloroacetic acid therapy have similar results in the treatment of anogenital warts.

Fixed drug eruption (FDE) is an uncommon adverse reaction to medications. Mucosal areas, particularly the male genitalia, are favored sites. To our knowledge, no study has investigated the causative agent(s) in FDE occurring on male genitals of Iranian patients. So, we conducted a study to determine the most common agents and areas of involvement in fixed genital drug eruption of male patients.
Diagnosis of FDE was supported by a positive history and physical examination. Data including age, site of lesions, time interval between drug administration and FDE development was collected and analyzed.
The age range of the 36 male patients was 17 to 60 years with a mean age ± standard deviation of 36.1±10.9 years. The most common causative drug was co-trimoxazole in 33 patients (91.7%). In the genital area, the most frequent involved site was the glans penis in 22 patients (61.1%), followed by the penis shaft in 11 patients (30.6 %) and the scrotum in 2 patients (5.6%).
The most common causative drug is co-trimoxazole and the most common site is the glans penis.

Griscelli syndrome (GS) is a rare autosomal recessive immune deficiency disorder that presents with pigmentary dilution of the skin and hair, recurrent skin and pulmonary infections, neurologic problems, hypogammaglobulinemia, and variable cellular immunodeficiency. Three mutations have been described in different phenotypes of the disease. In most of cases, GS leads to death in the first decade of life. In this article, we report a one-year-old child with type 2 GS who suffers from pigmentation disorder and hypogammaglobulinemia.

In this paper a locomotion control system for bipedal robot is proposed to provide desirable walking on a terrain and skipping over a pitfall preventing the robot from falling in it.The proposed strategy is a combination of motion optimization based on particle swarm optimization algorithm and utilization of mode switching at a higher level controller.The model for biped robot is a compass gait model but the method presented is general and could be appropriatly extended and generalized for other complicated models.

In this paper, the problem of the navigation error effect for the optimal and constraint Trajectory of the UAVs that are required to fly at low altitude over terrains has been discussed. Due to the increasing deviation problem of inertial navigation systems in terms of time, having a safe flight and collision avoidance with terrain at low altitude is the main point in the trajectory design of this type of the vehicles. On the other hand, some of these vehicles use Terrain Contour Matching (TERCOM) as a navigation aiding system. This system is more efficient in rough terrains, and providing the requirements of this system beside other constraints is a complex task. In this paper is tried to meet these constraints in the trajectory design process. For this purpose, an algorithm based on the layered network flow on the digital terrain maps used in a manner that has a high potential in adoption of various constraints and optimal trajectory is generated. Then, using equations of motion on a terrain digital data in 3D space with the dynamical constraints and different optimality criteria, a complete model of navigation error and also parameters affecting TERCOM has been developed to generate feasible path reducing terrain collision probability to zero.. Numerical results show validity of this issue.

leishmaniasis in Iran is a major healthcare problem. Epidemiological studies are effective in disease control and preventive measures. The aim of this study was to investigate the epidemiology of cutaneous leishmaniasis in Razavi Khorasan province in 2011. This descriptive-analytical survey was conducted on cutaneous leishmaniasis patients in 2011. Recorded demographic and epidemiological information of patients were extracted from disease surveillance department of Mashhad university of medical sciences. Data were analyzed by SPSS version 11.5. The number of cutaneous leishmaniasis patients was 3558. According to the population coverage of Mashhad university of medical sciences, disease incidence was 7.2/10000 and 52% of patients were men. Most cases were children (under 10 years old) and youth (20-30 year old). Highest disease frequency was observed in students and housewives. The disease incidence in Torghabeh _Shandiz, Sarakhs and Daregaz was 92.3, 27.6 and 16 cases per ten thousands people, respectively. The disease incidence in Razavi Khorasan was moderate compared to the other endemic areas of Iran. However, this frequency was still significant. According to high disease incidence in children and housewives, these groups needed to be trained in disease prevention and increase their level of health literacy.

Psoriasis is an inflammatory and proliferative disease. Psoriasis clinical features vary from plaque-type psoriasis to pustular form. Psoriasis is an immune-mediated disease, which affects epidermal keratinocytes. Regard to serious side effects of chemical therapy in psoriasis patients, various projects were performed all around the world to find new therapeutic approaches for psoriasis. Various studies confirmed that Indigo naturalis treatment induced long-term remission in patients with psoriasis in all ages.

Exfoliative dermatitis is a rare disorder with several etiologic factors. The frequency of different etiologies varies in the medical literatures. The purpose of this study was to reveal the demographic characteristic and etiologies of exfoliative dermatitis in our department. We reviewed the records of the patients who were admitted to the dermatology ward of Ghaem Hospital, Mashhad, Iran, with a diagnosis of exfoliative dermatitis in a twenty-year period (1982-2002). Age, gender, the cause of exfoliative dermatitis, and the most probable drug cause were studied. Fifty-nine cases were included in the study. Male-female ratio was 1.27:1. The mean age of the patients was 50.11±19.37. The most common causes were psoriasis (40.7%), drugs (18.6%) and lymphoma (18.6%). The most common drugs that caused exfoliative dermatitis were co-trimoxazole (27.27%), carbamazepine (18.18%), and gold salts (18.18%). The most frequent of underlying cause of exfoliative dermatitis in our series was psoriasis. Co-trimoxazole was the most common drug that caused exfoliative dermatitis.

In this paper, various identification methods based on least-squares technique to estimate the unknown parameters of structural systems with hysteresis are investigated. The Bouc-Wen model is used to describe the behavior of hysteretic nonlinear systems. The adaptive versions are based on the fixed and variable forgetting factor and the optimized version is based on optimized adaptive coefficient matrix. Simulation results show the efficient performance of the proposed technique in identification and tracking of hysteretic structural system parameters compared with other least square based algorithms.