جستجوی مقالات مرتبط با کلیدواژه « پروتئین کلوتو » در نشریات گروه « پزشکی »

Klotho protein is a substance effective in increasing life expectancy. Moreover, it prevents muscle atrophy, osteoporosis, and cardiovascular disease. Therefore, the present aimed to assess changes in the expression of klotho protein and insulin-like growth factor 1 (IGF-1) genes in the muscles of aged Wistar rats after eight weeks of resistance training.

The present experimental study was connected on 16 Wistar male rats, aged 20 months, which were assigned to two groups of resistance training group and control. Resistance training was performed three sessions a week over eight weeks. After dissecting the rats, the soleus and flexor hallucis longus muscles of the rats were extracted to measure the expression of klotho protein and (IGF-1) genes using the real-time polymerase chain reaction technique.

After the resistance training program, Klotho protein in the fast-twitch muscle tissue of the trained rats did not show a significant difference, compared to that in the control group. Furthermore, IGF-1 in the fast-twitch and slow-twitch muscles of the training group did not display a marked difference, compared to that in the control group.

As evidenced by the obtained results, the values of klotho protein and IGF-1 did not improve after a period of resistance training. It can be argued that resistance training should be conducted in longer periods and with different intensities, which should be scrutinized in future research.

Cardiovascular problems and atrial fibrillation is one of the most prevalent secondary consequences in hemodialysis patients. This study aimed to examine the effect of high intensity interval training on the level of atrial fibrillation, fibroblast growth factor 23 and Klotho in male rats with chronic kidney disease.

In this study, 30 male rats Wistar (7-8 weeks) were randomly assigned into three groups of exercise, control and sham. Rats in the exercise and control groups were entered to the study by using nephrectomy 5/6Nx, which made renal failure. Exercise protocol included training protocol as high intensity interval training (85% Maximum oxygen consumption) on treadmill for 8 weeks and three sessions in each week. Atrial fibrillation, fibroblast growth factor 23, Klotho, and other parameters were examined at the post intervention in all three groups. Data analysis was performed by one-way ANOVA and to examine the difference between groups, followed post-hoc Bonferroni analysis test at P <0.05.

Interval training was able to make a significant difference between the exercise and control groups in the level of atrial fibrillation (P<0/05). Klotho protein also had a considerable increase in the exercise group compared to the control group. However, the fibroblast growth factor 23 did not differ significantly between the exercise and control groups (P>0/05).

High intensity interval training can cause a significant decrease in the level of atrial fibrillation in chronic kidney patients; however, in the process of this improvement, the changes in fibroblast growth factor 23 and related factors are less and the role of Klotho protein has an important effect.

The percentage of elderly people is growing in our country. Aging is associated with multiple diseases, disabilities and heavy medical expenses. The new multi-functionalProtein, Klotho, not only reduces the aging process but also affects several diseases associated with older ages.The aim of this study was to evaluate the effect of vitamin D supplements on the plasma levels of klotho in the elderly. This study was conducted in a randomized clinical trial in 81 elderly, with insufficient vitamin D plasma levels (10-30 ng/ml) for 12 weeks.Individuals randomly divided into two groups of vitamin D supplements (50000 IU) and placebo once a week. Vitamin D was measured by chemiluminescence method and klotho by ELISA. Data was analyzed by SPSS (version 22) software at meaningful level of P <0.05. 25(OH)D levels were increased and decreased significantly in vitamin D and placebo group respectively (p<0.001 & p<0.001 respectively), and its changes between the two groups was significantly different at the end of the intervention (p<0.001). The mean klotho protein levels and its changes after the intervention were significantly different between the two groups (p=0.014 & p<0.001 respectively). The mean klotho protein levels in the vitamin D group was not change significantly (p=0.164). The findings of this study showed, weekly intake of 50,000 IU vitamin D for 12 weeks in elderly peoplewith insufficient vitamin D levels, caused significant difference in klotho protein and vitamin D changes between the two groups, and also vitamin D levels in vitamin D group was increased significantly at the end of the intervention.