Association of adiponectin gene (rs 2241766) polymorphism and colorectal cancer in Tehran, Iran

Many studies have been shown association between low level of Adiponectin hormone and insulin resistancy, obesity and increased risk of colorectal cancer. The goal of this study was to evaluate prevalence of polymorphism of Adiponectin gene rs 2241766 in Tehran, Iran and to check the role of this polymorphism in increased risk of colorectal cancer. In this case- control study, genotyping of the Insulin gene were determined in 107 colorectal cancer patients and 107controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP).The statistical analysis was done using SPSS ver.16. Polymorphism of Adiponectin rs 2241766 was not a predisposing factor to increased risk of CRC (p=0.29). The genotype GT compared with TT, was not associated with increased risk of CRC (OR=1.02, CI=0.52-1.97; p=0.95), but GG versus TT (OR=0.015, CI=0.29-0.78; p=0.025) was associated with decreased risk of CRC. Frequency of mutant allele hadnt significant difference between patients and controls (OR=7.34, 95% CI=0.45-1.19; p=0.21). These findings suggest that polymorphism of adiponectin rs 2241766 isnt associated with increased risk of CRC.