Evaluation of analgesic effect of glucose - insulin - potassium in acute myocardial infarction

chest pain control is one of the most important components of guidelines for acute myocardial infarction. An analgesic effect of glucose, insulin potassium solution has been suggested in a few studies. Hence this study was performed to evaluate the effect of this solution on the intensity of chest pain in patients with myocardial infarction. This randomized clinical trial enrolled 72 patients who had myocardial infarction that was treated with 25% glucose, 50 unit of soluble insulin per liter, and 80 mille mol of potassium chloride per liter at 1 ml/kg/hour (case group) or normal saline (control group) as adjunct to thrombolytic therapy. We evaluated pain intensity at baseline, after receiving thrombolytic therapy and 1 hour later, in both groups by a Numeric Rating Scale. Statistical analysis was performed using SPSS 15. Variables were compared using independent t tests and repeated measure ANOVA or chi-square test. In both groups pain intensity after receiving streptokinase and an hour later dropped, but there was no significant differences between two groups (P = 0.121). Difference between intravenous drug consumption in the two groups was not significant (P = 0.93). The administration of potassium, glucose, insulin has no effect on chest pain in patients with myocardial infarction.