Evaluation of the relationship between Glucose tolerance test and essential hypertension

In regard to the high prevalence and multiple sequelae of hypertension, it is necessary to investigate its etiologic causes. This study was carried out in order to evaluate the relationship between impaired GTT and essential hypertension to plan further studies for prevention and treatment of essential hypertension. Samples have been randomly selected from people older than 40 years without history of diabetes mellitus or hypertension without using drugs affecting these two diseases. In this study, after excluding the samples with secondary hypertension, 135 samples have been evaluated and divided into three groups depending on the value of the blood pressure. Data have been analyzed by SPSSv6/win software using one way ANOVA, chi-square and the student t-test. Significant relationship was not found between hypertension and fasting blood sugar (P>0.05) however there was a significant relationship between hypertension and OGTT1/2, OGTT1 and OGTT2 (P<0.05). The prevalence of FBS>126 mg/dl was not significantly different between three groups (P>0.05). The prevalence of impaired GTT in those with moderate hypertension was 14.6 fold greater than normal population an this was 2.65 fold greater than those with mild hypertension (P<0.05). In mild hypertensives the value 2.65 fold greater than normotensives (P<0.05). No relationship was found with age and sex. Body mass index in hypertensives was significantly higher than normotensives (P<0.05). A significant relationship was shown between essential hypertension and impaired GTT. Also in hypertensives the prevalence of impaired GTT and diabetes mellitus was higher than normotensives. Therefore a direct relationship was shown between the stage of hypertension and the degree and the prevalence of impaired GTT.