A Combination of Vitamin C and Losartan for Cisplatin-induced Nephrotoxicity in Rats

Author(s):

Farzaneh Ashrafi , Mehdi Nematbakhsh , Tahereh Safari , Ardeshir Talebi , Hamid Nasri , Mehdi Khazaei , Mohammad , Mehdi Baradaran , Mahdavi , Amir Jafapisheh , Behrooz Olia , Omid Pirhaji , Sayyed , Javad Hashemi , Nia , Fatemeh Eshraghi , Zahra Pezeshki , Mojgan Mortazavi

Abstract:
Introduction
The nephroprotective effect of co-administration of vitamin C and losartan as prophylaxis against cisplatin-induced nephrotoxicity (CIN) was evaluated.
Materials And Methods
Co-administration of vitamin C and losartan was compared with losartan (10 mg/kg), vitamin C (250 mg/kg), and placebo in 4 groups of rats with CIN. The prophylactic agents were injected daily for a period of 4 days, and on day 3, a single dose (6 mg/kg) of cisplatin was administrated. The animals were sacrificed 7 days later for pathological examination of the kidneys.
Results
Cisplatin prevented the animal's weight gain. The serum levels of creatinine and blood urea nitrogen increased within the groups with CIN, but no significant difference was observed between the groups. The prophylaxis has no effect on serum osmolality, total protein, or nitrite concentrations. The kidney tissue damage was scored, and losartan provided a lower damage score than vitamin C and a combination of vitamin C and losartan.
Conclusions
We concluded that co-administration of vitamin C and losartan was not more effective than the administration of vitamin C or losartan alone.
Language:
English
Published:
Iranian Journal of Kidney Diseases, Volume:6 Issue: 5, Sep 2012
Pages:
361 to 365
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