Comparative Investigation of Blood Hemocystein-Level in Women with and without Preeclampsia

Hypertension is a common complication during pregnancy and its association with bleeding and infection causes maternal mortality and morbidity. Preeclampsia is a complex multi-organic disorder with extended vasospasm. According to some reports، there is a relationship between the increase of blood hemocystein-level and cardiovascular disorders in preeclampsia. Therefore، this research has been done with the aim of investigation of blood Hemocystein concentration in women with and without preeclampsia. This cross-sectional case-control study was conducted among 70 singleton-pregnant women in third trimester who were admitted to the selected hospitals of medical university of Mashhad and had inclusion criteria. 35 women with preeclamptic signs were selected as case group and 35 women with normal blood pressure and no proteinuria were selected as control group. While diets and taken supplements of both groups were similar، effective variables on occurrence of preeclampsia were monitored. Demographic characteristics were filled in questionnaire form and homocysteine levels were measured. The gathered data were analyzed by SPSS software (version 16)، T-test، chi square، two way ANOVA. P value less than 0. 05 was considered statistically significant. Both groups were homogeneous in ages، pre-pregnancy BMI، gestational age، number of pregnancy، and hemoglobin level. Blood homocystein level was not statistically significant in both groups (9. 16±4. 54 in preeclamptic group vs. 8. 22±3. 38 in normal group) Preeclamptic women had higher level of blood hemocystein in comparison with non-preeclamptic women but this difference was not significant.