مجله زنان مامائی و نازائی ایران
سال پانزدهم شماره 15 (هفته اول شهریور 1391)

Restless-leg Syndrome is a movement-disorder which is characterized by intense desire of moving legs during the rest. Patients often experience brief involuntary muscle jerks leading to sleep disturbance. The present study has been implemented to investigate the relationship between restless-leg syndromes and sleep disturbance in pregnant women. This descriptive cross-sectional study with accessible sampling was performed on 110 pregnant women who referred to office of Saqqez gynecologists in 2011. A questionnaire was used for data collection; the first part of which was about demographic information. Restless Legs Syndrome screening questionnaire and Athens Insomnia Scale for assessment of sleep quality، Epworth Sleepiness Scale for assessment of drowsiness during the day were used، as well. Data were analyzed by SPSS software (Version16)، t-test، and chi-square. P value less than 0. 05 was considered statistically significant. The results showed that 22. 7 percent of pregnant women suffered from restless-leg syndrome. There was a significant association between restless-leg syndrome and sleep quality disturbance (p<0. 01) and excessive day-sleepiness (p<0. 04). Results of the study indicated a significant association between restless-leg syndrome and sleep quality disorder during pregnancy.

Some studies indicated that mood-changes were more common peri menopause rather than premenopausal period. This study was held by the aim of assessing the prevalence of two common mood-changes in this period: depression and anxiety، and their relation with socio-somatic and demographic factors. This cross-sectional study was done on 201 women of 45 to 60-year-old who had not suffered of psychological diseases. Three questionnaires including: Socio- demographic characteristics، Menopausal rating scale (MRS)، and Symptom Checklist-90 (SCL90) were completed by them. Their follicle-Stimulating hormone and estradiol levels were also checked. The obtained data were analyzed by statistical SPSS software version 17 and chi square test. P value less than 0. 05 was statistically significant. The prevalence of depression and anxiety were found 20. 9% and 20. 4% respectively in this study. Analysis of Socio-demographic information showed a significant relation between anxiety and absence of husband. Also، there was a significant relation between mood-changes and symptoms of decreasing estrogen-level، urogenital symptoms، Vasomotor، somatic complications and decreasing of sexual desire. But association between estradiol، follicle stimulating hormone and mood-changes was not significant. In peri menopause women، there was relation between anxiety and decreasing of sexual desire and absence of husband. So there was relation between mood change and symptom of decreasing estrogen level.

According to the traditional believes Henna causes abortion; however، there is no scientific study in this regard and about its teratogenic effect. The aim of this research was to study the effect of Henna extract on congenital malformations in mouse. In this experimental study، a total of 120 female mice (30-40 gr، 8-12 week old) after mating and observing vaginal plug، were randomly allocated in 4 groups of control (Without intervention and distilled water injection) and case (Concentrations of 10 and 100 milligram per kilogram of Henna extract). All groups received daily intra-peritoneal injection for seven days. Cesarean operation was held on 18th and 19th day، as well. While height and weight measurements، embryos were examined for abnormalities. Data were analyzed by SPSS software version 11. 5، ANOVA and least significant difference (LSD) test. P value less than 0. 05 was statistically significant. A significant difference was observed in weight and length of fetuses in case and control group (p<0. 001) but there is no relevant difference among groups that received Henna. In 90% of case group، fetuses had no parietal bone and more extra ribs were observed in the groups who receiving Henna extract. Hydro-alcoholic extract of Henna has teratogenic properties، so it should be consumed with caution during pregnancy.

Hypertension is a common complication during pregnancy and its association with bleeding and infection causes maternal mortality and morbidity. Preeclampsia is a complex multi-organic disorder with extended vasospasm. According to some reports، there is a relationship between the increase of blood hemocystein-level and cardiovascular disorders in preeclampsia. Therefore، this research has been done with the aim of investigation of blood Hemocystein concentration in women with and without preeclampsia. This cross-sectional case-control study was conducted among 70 singleton-pregnant women in third trimester who were admitted to the selected hospitals of medical university of Mashhad and had inclusion criteria. 35 women with preeclamptic signs were selected as case group and 35 women with normal blood pressure and no proteinuria were selected as control group. While diets and taken supplements of both groups were similar، effective variables on occurrence of preeclampsia were monitored. Demographic characteristics were filled in questionnaire form and homocysteine levels were measured. The gathered data were analyzed by SPSS software (version 16)، T-test، chi square، two way ANOVA. P value less than 0. 05 was considered statistically significant. Both groups were homogeneous in ages، pre-pregnancy BMI، gestational age، number of pregnancy، and hemoglobin level. Blood homocystein level was not statistically significant in both groups (9. 16±4. 54 in preeclamptic group vs. 8. 22±3. 38 in normal group) Preeclamptic women had higher level of blood hemocystein in comparison with non-preeclamptic women but this difference was not significant.