Pathological lesions and enzyme changes in liver tissue of mice induced by injection of new designed nanoemulsion

In present study, we have investigated the toxicity of a new designed nanoemulsion on mice liver.A total number of 60 male mice with the average weight of 30-40g were selected. The experiment groups of mice received 500ML nanoemulsion via I.P. injection and after interval times of 1, 5 and 10 days, toxicity studies were done using histochemical techniques and assay of different liver enzymes (ALT, AST and ALP) in all groups. Results of histochemical studies did not show significant changes in the numbers of Kupfer and hepatocyte cells and ports diameters; whereas the organization of liver cells was changed, which considered as a side effect of nanoemulsion. Also, results of liver enzymes did not show significant difference in experiment groups relative to control (P>0.05). According t resultos, we can be concluded that new designed nanoemulsion (500 ML) had not serious side effects on mice, and then this nanoemulsion might act as a drug carrier especially anticancer drugs.