Immunomodulatory effects of pomegranate juice, Date palm and fig fruits on prevention and treatment of experimental acute colitis model in male rat

Inflammatory bowel diseases (IBD) are the one of the most comment alimentary diseases. Etiology and pathogenesis of IBD remain obscure. There is substantial evidence that proinflammatory cytokines such as Interleukin-6 (IL-6) and Tumour Necrosis Factor-alpha (TNF-alpha) exhibit a key role in the inflammatory process. In the last decade investigations were done on treatment and pretreatment effects of some modulators and inhibitors of these mediators which emphasize different aspects of experimental colitis models mimicking IBD in human. The aim of this study is investigation of therapeutic and prophylactic effects of pomegranate، fig and date in daily regimen in experimental acute colitis model on rat. The results of this study show that pomegranate juice induces both therapeutic and prophylactic effects and date has only therapeutic effect on colitis.