Effect of Coenzyme Q10 Supplementation on Serum Creatine Kinase, Leukocytosis, Thrombocytosis and Blood Lipid Profile in Inactive Men after an Aerobic Exercise

In accordance with the limited studies about effect of coenzyme Q10 ingestion on exercise-induced response of biological indices, this study was conducted to identify the effect of short-term coenzyme Q10 supplementation on serum total creatine kinase (CK), leukocytosis, thrombocytosis, and blood lipid profile in inactive men after one bout aerobic exercise. Twenty healthy inactive men (aged 22-26 years, 13-16% body fat, and VO2max 38-42 ml/kg/min) in a randomized and double-blind design were allocated in two equal groups: supplement and placebo groups (intake 2.5 mg/kg/day Coenzyme Q10 or dextrose). After 14-days supplementation, all subjects were participated in an aerobic exercise with 75% VO2max on the treadmill for 30 minutes. Blood samples obtained before Q10 supplementation along with before and after the exercise protocol. Data were analysed using repeated measure ANOVA, Bonferroni and independent t test (P<0.05). Results showed that short-term coenzymQ10 supplementation has no significant effect (P<0.05) on all of parameters (except TG and HDL). Aerobic exercise significantly increased CK, aggregation platelets and leukocytes number, whereas caused decreasing serum TG and LDL and triglycerides (P<0.05). Finally, platelet aggregation and leukocytosis in the supplement group were less than placebo group after aerobic exercise (P<0.05). The present results showed that 14-days coenzyme Q10 supplementation can improved basal blood lipid profile and reduced leukocytosis and thrombocytosis in inactive men induction aerobic exercises.