EXPRESSION OF ADRENERGIC RECEPTOR BETA-2 AND FMD LEVEL IN UNTRAINED MIDDLE-AGED MEN: EFFECT OF EIGHT WEEK REGULAR EXERCISE TRAINING

This research was aimed to investigate hypertension Adrenergic Receptor B2 (ADRB2) gene expression and Flow Mediate Dilation (FMD) level in untrained middle-aged men fallowing to eight week regular exercise training. This study was a semi-experimental research with a repeated measures design. From 96 volunteer middle-aged men, 20 subject (age range of 45-55 years) participated in this study after signing an informed consent form. Next, subject divided in two groups of training (10 person) and control (10 person) groups and performed the eight week moderate exercise training (time: 45 minutes, speed: 50-65 maximal hear rate, slope: 0%). These factors (ADRB2 and FMD) were investigated in three times: baseline, after 4 week and after 8 week. Real time- PCR was used for evaluation of Adrenergic Receptor B2 (ADRB2) mRNA and Pulsed Doppler Velocity Signal for Flow Mediated Dilation (FMD). ADRB2 gene expression in training group were significant increased after four and eight week exercise training (P<0.001) but this receptor expression was significant increased after four week being untrained in control group (P= 0.026), but decreased after 8 week (P=0.386). FMD level was significant increased in training group after 4 and 8 week (P=0.001), in control group, FMD were not significant changes after 4 week being untrained (P=0.35), but after 8 weeks being untrained, significantly decreased (P=0.010). Regular exercise training has increased the expression of ADRB2 and FMD level in middle-aged men, but untraining decreased this factors.