Evaluation of Serum Cardiac " Troponin I" in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is a limiting air flow disease that does not cure completely, and is estimated that will be the third cause of death until 2020. COPD exacerbation is the main cause of reception of patients with status COPD in hospitals. Life quality in patients with COPD is related to frequency of attacks. Biomarkers such as serum cardiac troponin I, like cardiac diseases, may become positive in COPD during acute attacks and may have a prognostic role in patients admitted due to COPD. Patients with COPD exacerbation presented and admitted in Imam Reza hospital and Research center of pulmonary diseases from Jan 2010 to Mar 2011enrolled for our study. Sample size was determined as non-randomized, simple and available and was estimated 72 patients. In our patients, cardiac troponin I did not have any relationship with sex or age, mean arterial blood CO2, and FEV1, but mean arterial blood O2 in patients with negative cardiac troponin I, was 44.40±10.25 and in patients with positive cardiac troponin I, was 50.97±15.77 mmHg, that had significant difference (p=0.03). In positive cardiac troponin I patients, arterial blood O2 was more than patients with negative cardiac troponin I; that may be due to prescription of more oxygen due to worse clinical status.