The Effect of Hydro-Alcoholic Extracts of Ginger on Lead Detoxification of Kidney in the Immature Wistar Rats

Ginger has pharmacological properties because of its active compounds. The aim of research was to assess the damages on poisoned rat’s kidney by lead using protective effect of different aqueous-alcoholic ginger extract. In this experimental study the immature rats were divided into 7 groups of 10. The first group، control، without receiving any substances، the second group، sham، received 0. 1 ml distilled water، the third group، with only lead، receiving 0. 6gr/l/bw، forth group just received 2 gr/kg ginger alcoholic- water extract، the 5th، 6th، 7th received 0. 6gr/l /bw lead and 0. 5، 1، 2gr/l /bw ginger aqueous-alcoholic extract، respectively. The animals were fed with the given compounds for the 10 successive days. Plasma were evaluated for the concentration of uric acid، urea، creatinine، sodium and potassium. T-test was used for data analysis. According to the results، the serum levels of uric acid، creatinine and potassium showed significant reduction in the concentration of 1، 2 gr/kg/bw as compare to lead (p ≥ 0. 05) and sodium levels showed significant increase in concentration of 0. 5، 1، 2 gr/kg comparing to lead treated animals (p ≥ 0. 05). Aqueous-alcoholic extract of ginger on the kidney cells of poisoned immature rats by lead had a profound protective effect which is mainly due to ethanol and phenol components which lead to neutralize the free radicals and stimulation of kidney cells to repair because of its antioxidant properties.