The comparison of estrogen metabolites between active and inactive postmenopausal women

Regular physical activity may alter estrogen metabolism. The purpose of the present study was to compare estrogen metabolites between active and inactive postmenopausal women. 75 postmenopausal women were asked to complete Baeck questionnaire. Based on the questionnaire scales، they divided into two groups: active and inactive. Blood samples were taken in fasting state from all subjects and serum concentration of 2-hydroxyestron and 16-hydroxyestron metabolites and their ratios measured. Independent T test is used for data analyzing. The results showed that 2-hydroxyestron metabolite level and 2-hydroxyestron/16-hydroxyestron ratio were significantly higher among active postmenopausal women than inactive postmenopausal women but 16- hydroxyestron metabolite level was significantly lower among active postmenopausal women than inactive postmenopausal women. It can be said that long-term physical activity by influencing on estrogen metabolites can reduce breast cancer risk in postmenopausal women.