Effect of bromocriptine on disease activity in rheumatoid arthritis
Author(s):
Abstract:
Background
Bromocriptine، as an Ergot alkaloid، suppresses prolactin synthesis. Some clinical studies support the role of prolactin in the development of rheumatoid arthritis (RA) disease activity. Therefore، this study aimed to examine the effect of bromocriptine on disease activity in RA. Materials And Methods
This double-blind interventional study was performed on 174 patients with rheumatoid arthritis referred to Shahid-Beheshti hospital in Kashan during 2011-2012. The patients were allocated into the two groups through block randomization. One group received bromocriptine 2. 5 mg two times a day and another group received a placebo. All patients were examined at the beginning and during the second and six months of the study for swelling، tenderness، pain severity based on disease activity score (DAS)، erythrocyte sedimentation rate (ESR) and visual analogue scale (VAS)، respectively. Results
Results indicated that in bromocriptin group، initial swelling، pain severity and initial DAS significantly decreased from 3. 7 to 0. 59; 82. 1 to 23. 15; 3. 8 to 3. 5، respectively after 6 months compared with those in the control group. Moreover، no significant decrease was observed in the ESR and tenderness parameters. Conclusion
Bromocriptine can reduce swelling، pain severity and DAS in RA.Keywords:
Language:
Persian
Published:
Feyz, Volume:17 Issue: 4, 2013
Pages:
373 to 379
magiran.com/p1171886
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!