The effect of eight weeks endurance training at different durations on brain derived neurotrophic factor (BDNF) of hippocampus in male rats

Introduction and Neuroplasticity is defined as to the brain and central nervous system's ability to adapt to environmental changes and its function. The aim of this study was to investigate the effect of 8 weeks endurance training at different durations on hippocampal BDNF in male rat. Forty adult Wistar male rats (6–8 weeks old, 189
10g) were randomly divided into four groups: control, Sham, 30 min/session trainingand 60 min/sessiontraining. Training consisted of treadmill exercise at 20 m/min (0% grade) for 5 days/week for 8 weeks. Rats were sacrificed 72 h after the last session of exercise for measurementof BDNF levelsin the hippocampus. BDNF content in the hippocampus tissue was determined with ELISA Kit. Data were analyzed using oneway ANOVA and LSD. Hippocampal BDNF content was significantly higher in 60 min/session training group than control (0002), sham (0006) and 30 min/session (002) groups. 30 min treadmill training did not change the BDNF content in rats hippocampus (P=0354).Discussion and The result of this research shows that endurance training with moderate intense and duration (60 minute) in comparison with shorter duration (30 minute) cause more increase hippocampal BDNF levels in rats.