Changes of adipose tissue visfatin gene expression in response to one session exercise in the streptozotocininduced diabetic rats

Diabetes is a metabolic disorder that caused followed the decline in insulin secretion or insulin resistance. Visfatin is a recently discovered protein that is expressed andsecreted in visceral fat tissue that will improve insulin sensitivity. The purpose of this study was to explore of one session of aerobic exercise on visceral adipose tissue visfatin gene expression in rats with diabetes type 2. diabetes in this experimental study was induced by streptozotocin (50 mg/kg) injection in single dose in mice. 20 male wistar rats with average weight of 165 ±5 g were randomly divided into a control group and three exercise groups. The training groups run a session with a speed of 20 meters per minute for 45 minutes on the treadmill. Rats were anesthetized in separated group, immediately, 4h after exercise and 24h afterexercise and sampling were done. Finally, to determine the relative levels of gene expression, semi-quantitative RT-PCR was performed. The results showed significantly increased expression of visfatin in 4 h and 24 h after exercise compared with the control group (P<0.05).Discussion and In summary, exercise can improve the visceral fat tissue levels of visfatin mRNA expression. Increasing the visceral fat tissue visfatin mRNA suggested thatvisfatin in visceral fat tissue could possibly act as Paracrine and also may be play important rol in glucose and lipid metabolism.