Non-Alcoholic Fatty Liver Disease: Diagnosis and Evaluation of Disease Severity
Author(s):
Abstract:
Context: Considering the increasing prevalence of obesity and insulin resistance syndrome worldwide, non-alcoholic fatty liver disease (NAFLD) has become a major health concern. Early diagnosis and proper management might prevent disease progression. The aim of this article is to review the current knowledge on the diagnosis and evaluation of disease severity in NAFLD..Evidence Acquisition: After excluding causes of liver cell damage, the patients with persistent aminotransferase levels and well-defined criteria for fatty liver at ultrasonography are presumed to have NAFLD. When concomitant liver disease exists, the diagnosis of NAFLD is questionable without liver biopsy. Considering the limitations of diagnostic methods, selection of the best diagnostic approach has become a conflicting issue in NAFLD..
Results
The review of literature showed that clinical findings, imaging studies, and laboratory investigations are commonly used for the diagnosis and the evaluation of disease severity in NAFLD. The results of non-invasive methods are sometimes inconclusive. The histological information is necessary for confirming the NAFLD diagnosis in this occasion. Meanwhile, invasiveness and possible complications make the liver biopsy an unacceptable method for most patients. It is not recommended routinely when the clinical and paraclinical findings are apparently in favor of NAFLD..Conclusions
In view of the limitations of the above-mentioned modalities, liver biopsy remains the gold standard method for documentation of diagnosis and estimation of disease severity in NAFLD..Keywords:
Language:
English
Published:
Thrita, Volume:2 Issue: 6, Dec 2013
Pages:
43 to 51
magiran.com/p1205953
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!