Study of psuedomomas aeroginosa resistance to Ceftizidim and Imipenem in Kermanshah Imam reza hospital during 2006-2011

Pseudomonas aeruginosa is one of the most important organisms of nosocomial infections that can cause a wide range of infections in immunocompromised patients. Therefor، in this research we studied the antibiotic resistant of this important organism against Ceftazidime and Imipenem as the most important drugs against Pseudomonas aeruginosa. All specimen of blood، urine، liquids and… submitted to the laboratory of kermanshah Imam Reza hospital for culture during 5years (2006-2011) were selected and cultured on EMB،BA،and differential media. After the diagnosis and isolation of Psuedomomas aeroginosa، antibiogram profile of the bacteria was determined by disk-diffusion test (Kirby-Bauer) and interpreted according to NCCL standards. During five years،364 Pseudomonas aeruginosa were isolated in this center. The highest incidencewas isolated from urine samples (51/5 %). The results showed that the the rate of Ceftazidime and Imipenem resistance was 56 % and 24. 7 % respectively. This results reveal an annual increased rate of resistancy. It was observed in this study that the rate of resistance to these two antibiotics has increased during last five years which is in accordance with studies done in the region and neighbor countries، but it shows a significant difference with the studies done in of the industrial countries. This matter indicates the importance of proper use of these antibiotics in developing countries.