Association of serum N-Terminal pro BNP in the Prediction Association of Serum N-Terminal pro BNP in Prediction of Left Ventricular Ejection Fraction in Patients with Systolic Ventricular Dysfunction

Background and Annually heart failure includes about three million emergency outpatient visits in the United States. In heart failure NT-proBNP will be released in response to increased myocardial stretch This study was conducted in 80 individuals attending Fatemeh Zahra Hospital، in Sari، 2010-2011. Patients with GFR≤60، age≥75، atrial fibrillation (AF) and hypertension (BP≥160. 100) were excluded. The patients were carefully examined and 60 patients with DHF were divided into three groups; Group1 LVEF≤30%، group 2 LVEF≤31-39%، group 3 LVEF≤40-49%. Twenty healthy people with normal LVEF≥50% were also studied to determine the cut point. The highest level of NT-pro BNP was observed in group 1 (5370. 10 ± 1781. 90) and the lowest level was seen in group 4 (36. 75 ± 24. 32). Significant differences were found between the groups in NT-pro BNP level (P<0. 001). Also، incomplete and reverse correlation was observed between LVEF values and serum level NT-pro BNP (R= -0. 699). When LVEF reduced NT-pro BNP levels increased significantly which indicates an incomplete and reverse correlation between them. This finding allows using NT-pro BNP level for approximate estimation of ejection fraction in clinical practices.