Effect of Otostegia persica's root extract on the blood biochemical factors in diabetic hyperlipidemic rats

Considering the multidimensional activity of herbal medicines and the usefulness of this drugs to treat complex disorders such as diabetes، this study was done to investigate the effect of aqueous extract of Otostegia persica’s root on blood lipids and lipoproteins levels in hyperlipidemic diabetic type I rats. This experimental study was done on 48 male Wistar rats. All ethical issues related to the keeping and work with laboratory animals was observed. 40 rats with a single dosage of 90mg per each kilogram of body weight were induced type I diabetes by intraperitoneally injection of Alloxan. Rats were divided into 6 normal، control، metformin، 200mg، 300mg and 400mg/kg of Otostegia persica’s root aqueous extract groups each with 8 rats and they were gavaged once a day during a month. Levels of triglycerides، total cholesterol، LDL-C and HDL-C were measured in each group. The one-way ANOVA and Tukey''s tests were used to compare means of the groups. The mean of triglyceride، total cholesterol، LDL-C and HDL-C level in all three groups of Otostegia persica’s root aqueous extract compared to normal، control and metformin showed a significant decrease (p<0. 001). Using aqueous Otostegia persica’s root extract in hyperlipidemic diabetic rats decreases serum total cholesterol، triglyceride and LDL-C level.