Protective effect of Co-enzyme Q10 on seizure, short term spatial memory and oxidative stress in induced-epileptic rats
Author(s):
Abstract:
Background And Objective
Temporal lobe epilepsy is the most common type of epilepsy in human. Patients suffer from spontaneous seizures and memory deficiency. This study was done to assess the effect of Co-enzyme Q10 (CoQ10) administration on seizure، short-term spatial memory and stress oxidative indices in hippocampus of kainic acid-induced epilepsy. Methods
In this experimental study، 48 male rats were randomly allocated into six groups: sham-operated; CoQ10 (10 mg/kg/bw) -treated SH; kainate; CoQ10 (2، 5 and 10 mg/kg/bw) treated kainic acid. CoQ10 was intraperitoneally administered daily for one week before intra-hippocampal injection of kainic acid (4µg/kg/bw) in animals. Results
Kainic acid induced chronic and acute spontaneous seizures in animals. Also، kainic acid administration caused a reduction in alternational behavior rate (consecutive or serially entrance into all of arms in triplet set)، increasing of malondialdehide، nitrite level and decreasing of superoxide dismutase activity compared to sham group (P<0. 05). Pre-treatment of kainate rats with CoQ10 decreased rate of spontaneous seizures (P<0. 05). CoQ10 increased alternational behavior rate، decreased malondialdehide and nitrite serum level (P<0. 05). But it had no significant effect on superoxide dismutase activity. Conclusion
Pre-treatment of kainic acid exposed rats with CoQ10 reduced rate of seizures and improved short-term spatial memory and oxidative stress indices in rats.Keywords:
CoQ10 , Kainic acid , Temporal lobe epilepsy , Y maze , Malondialdehyde , Seizure , Rat
Language:
Persian
Published:
Journal of Gorgan University of Medical Sciences, Volume:16 Issue: 1, 2014
Pages:
14 to 21
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