Comparison of Effects of Injectable Contraceptives (Cyclofem and Depot Medroxyprogesterone Acetate) on Short Time Side Effects, Acceptability and Continuation Rates

The most common reason for discontinue depot medroxyprogesterone acetate in first year of using is correlated with menstruation disorders and weight gain. The aim of this study was determining and comparing the effects of cyclofem and depot medroxyprogesterone acetate on short time side effects، acceptability and continuation rates in women.

This clinical trial was conducted on 68 women who used contraceptive injections in Zahedan، Iran، 2010. During a period of 90 days، women registered bleeding events and possible side effects in the form of daily menstrual bleeding and side effects. User-satisfaction questionnaires were administered at 3 months after the first injection or earlier if a client decided to discontinue from the study. Data were analyzed using SPSS software version 18 and chi-square، Fisher exact test، t-test and Mann-Whitney tests. P value less than 0. 05 was considered significant.

The continuation rate for cyclofem was 52. 9% compared with 79. 4% for Depo-Provera. Nausea and mean of weight gain was showed significant differences in two groups (p=0. 01). Although user satisfaction was not statistically significant difference (p=0. 7) but main reasons in two groups for non- accepting was different.

Menstruation disturbances were main reason for non- accepting of Depo-Provera and difficult to come for visits was main reason for discontinuing of cyclofem.