Evaluation of plasma visfatin and metabolic indices response to aerobic training in type 2 diabetes women

Visfatin is a protein that secretes from adipose tissue. Previous studies have shown a direct relationship between plasma visfatin and type 2 diabetes but the effect of exercise training on the level of this hormone in the body is yet unknown. The purpose of the present study was to evaluate plasma visfatin changes and metabolic indices response to aerobic training in type 2 diabetes women. 40 women with type 2 diabetes (age 58/33±/26 y, and body mass index 32/25±3/69) were selected by avilable and purposive sampling and subjects were randomly divided into 2 groups. 20 subject were assigned to aerobic training group (12 weeks, 3 days/week, 20-50 min/days, 60-80% maximum heart rate) and 20 subject were were assigned to control group (who did not participate in any exercise program). Blood samples were collected for assess plasma visfatin, insulin, HbA1c, glucose, TG, TC, HDL, LDL levels before and after 12 weeks of the training regimen, and the data were analyzed by using SPSS software version 21, with a p value of <0/05 as statistically significant. Data analysis showed that 12 weeks aerobic training decreased visfatin, glucose, HbA1c, TG, CHOL, LDL-c levels. Also, there was a significant decrease in body weight, body mass index, body fat percent and waist-hip ratio in the experimental group as compared with the control group. The exercise-induced reduction of plasma visfatin is most likely the result of decrease in anthropometric and glycemic indices and improvement of the lipid profile.