The Effect of Twelve Weeks of Aerobic Training on ABCG1 Gene Expression in inactive obese Women

Introduction and ABCG1 protein is a membrane transporter is a key intermediary in the delivery of cholesterol from lipid-rich macrophages to apo-lipoprotein A. Which is one of the steps in reverse cholesterol transport body and final step in the prevention of atherosclerosis. ABCG1 Increased expression may prevent the formation of lipid-rich macrophages and consequently reduce the risk of atherosclerosisABCG1 transporter is responsible for making and forming of HDL particles and therefore probably plays a crucial role in preventionof Coronary artery diseases. The purpose of the present study The effect of twelve weeks of aerobic training on ABCG1 Gene expression in inactive obese women. 36 healthy women participated in this study and randomly assigned to control group (n=18) and experimental group (with an average age of 30- 35, BMI >30) (kg/m2)). Exercise program involved a12-week training with intensity of 65-75% of reserve heart rate done three days per week in one session of 55-60 minute period. Blood samples werecollected 48 hours before the first session and 48 hours after the last session (subjects were fasting). ABCG1 gene expression was measured using semi-quantitative-RT-PCR. Data were analyzed by t- test software. data analysis showed that expression of ABCG1 m- RNA was significantly increased following a single-session exercise in exercise group in Compared with the control group. It can be concluded aerobic exercise increases the expression of mRNA ABCG1 gene on in inactive Obese Women, and be effective in prevention of cardiovascular disease.