The Effect of D1 Dopamine Receptor Antagonist Administration into Ba-somlateral of Amygdala on ACPA Response in Fear Memory in Male Mice

Dopaminergic pathway has essentialrole in excitable behavior, especially fear. Cannabinoids are a class of psychoactive substances and impair memory. The aim of recent study is the effect f dopaminergic pathway in fear memory. In this research,the effect of D1 receptor antagonist Intracerebroventricular injection dopaminergic pathway and Arachidonyl cyclopropyl amide(ACPA) as impair on fear memory, in male mice was studied. One week after surgery of groups, in fear conditioning box, percent freezing and latency to first freezing was recorded. According to tukey test statistical analysis and one-way and two-way phase 5 min and 3 min, percent freezing ACPA dose of 0.1 mg/kg compared to the control group had a significant increase in latency. The percent freezing Dose SCH23390 0.08 μg/site in phase 5 min was significantly reduced in the 3min dose of 0.04 μg/site significant increase in latency indicated. According to Statistical test tow-way and tukey test showed that simultaneous injection ​​of SCH23390 (0.02 μg/mice) and doses of ACPA in phase 3 minutes to 5 minutes and has resulted in a significant reduction in latency and percent freezing. Results indicating that high doses of ACPA cause memory corruption and fear reduction as antagonist SCH23390 infusion D1 cause of the fear.