Determination of Prevalence Rate and Antibiotic Resistance Pattern in Pseudomonas aeruginosa Strains extracted from clinical samples of Tehran's Araad hospital between (2007-2010)

Pseudomonas aeruginosa is an important cause of nosocomial infection that is resistant to many antibiotics. the purpose of this study is to determine the sensivity and resistance of Pseudomonas aerogenusa strains that were isolated from clinical samples of patients who was admitted to Arad hospital in Tehran. In this descriptive examination, after extracting Pseudomonas aeruginosa derivations from clinical samples (urine, catheter, sputum, wound and bronchial), their sensitivity were measured using standard Kirby-bauer test, in contract with following antibiotics Amikacin, Ciprofloxacin, Gentamicin, Imipenem, Ceftriaxone, Sulfamethoxazole Trimethoprim, Piperacillin, Cefixime and Cefotaxime. In this study 261 samples of Pseudomonas aeruginosa isolated from clinical specimens in 4 years. The most sensivity was to Amikacin, Imipenem and Ciprofloxacin and the most resistance was to Cefotaxime, Sulfamethoxazole Trimethoprim and Cefixime. The results of this study are indicating that Pseudomonas aeruginosa strains resistance has increased against Cefotaxime, Sulfamethoxazole Trimethoprim and Cefixime; presumably due to excessive consumption of these antibiotics. It is obvious that, with increasing consumption of antibiotics, and consequently, augmentation of antibacterial resistance, control of this resistance factor is necessary and inevitable, we recommended to avoid unnecessary usage of antibiotics.