Effect of Intraperitoneal Glucose Injection on Passive Avoidance Memory in Adult Male Rats

Glucose is the major energy source for brain which passes across blood brain barrier easily and reach to neuronal cells. Following the intravenous injection of glucose, it’s concentration increases in blood followed by its increase in different parts of the brain such as Hippocampus. Hippocampus function in learning and memory has been confirmed from many years ago. This study aimed to investigate the effect of intravenous injection of glucose on passive avoidance learning in adult male rats using shuttle box apparatus. In this study, 21 adult male rats were divided into 3 groups including glucose receiving group (500mg/kg rat 10min pretraining), saline (glucose vehicle) and control group. Memory was examined 48 hours after training in shuttle box apparatus. Data was analyzed by SPSS 16 software using One-way ANOVA and then LSD test. There was no significant difference between control, receiving saline and glucose groups before training in terms of the latency to enter the dark compartment, whereas the significant difference was observed between the group receiving glucose and other groups in time spent in the light and dark compartments in the retrieval stage. Also the blood glucose concentration difference between the group receiving of glucose and other groups was significant. Intraperitoneal injection of glucose increases the passive avoidance memory of adult male rats in shuttle box apparatus.