Comparison the effects of naproxen, indomethacin and ibuprofen in treatment of spotting due to IUD insertion

IUD is one of the most effective and reversible methods of contraception with the widespread use worldwide. Spotting is the most important side effect of this method that due to discontinuing and removal of IUD. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are effective for treatment of spotting، but in previous study have not identified which one of these drugs is most effective. The aim of this study is to comparison the effects of naproxen، indomethacin and ibuprofen in treatment of spotting due to IUD insertion. This semi-experimental study was done in 2010. 943 women randomly allocated to naproxen group (250 mg/q 8 hrs)، indomethacin group (25 mg/q 12 hrs) or ibuprofen group (200 mg/q 6 hrs). Samples are women with IUD Cu T 380 A insertion during a month ago، referring to health centers of Karaj، Iran. All of samples completed 5 days duration of treatment and then they evaluated for spotting. Data analyzed using SPSS16 software with qui-square test، ANOVA and t-test. Significance level was considered 0. 95. All of three drugs were effective in treatment of spotting but base on qui-square test naproxen is the most effective one (p<0. 0001). The findings of this study show that naproxen is more effective than indomethacin and ibuprofen in treatment of spotting due to IUD insertion. Therefore we suggest 5 days protocol of naproxen for curing spotting due to IUD insertion.