THE EFFECT OF BISPHENOL A AND BISPHENOL AP IN A MOUSE MODEL OF POLYCYSTIC OVARY SYNDROME

PCOS (Polycystic Ovary Syndrome = PCOS) is a relatively common disease in women of childbearing age. Bisphenol s are chemical groups that are composed of two functional hydroxyl group and most of them are based on methane. In this study, the effects of phenolic compounds, (bisphenol A and AP) in polycystic ovary syndrome were investigated. mature Wister rats were classified in six groups. Healthy controls (healthy rats that received Grape seed Oil as solvent), PCOS Group (disease induced by testosterone propionate) experimental groups 1.2.3.4, respectively. after induction of PCOS,they received bisphenol- A and AP in doses of25 mg / kg, 50mg/kg, by gavage. Blood samples were taken and the hormones LH, FSH was measured. Ovaries were also to be studied histologically. The results showed that the amount of LH to FSH ratio increases after induction with bisphenol-A and bisphenols AP,. Furthermore the number of follicles and growing follicles were reduced significantly, and these concequences causing negative effects on polycystic ovary syndrome.